| 香术茯苓颗粒的镇痛和抗菌作用 |
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| 引用本文： | 王宇翎,吴文宁,林杰,杨梦媛,朱韬,罗欢.香术茯苓颗粒的镇痛和抗菌作用[J].安徽医科大学学报,2015,50(12):1770-1772. |
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| 作者姓名： | 王宇翎 吴文宁 林杰 杨梦媛 朱韬 罗欢 |
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| 作者单位： | 安徽医科大学基础医学院药理学教研室,合肥,230032;安徽医科大学基础医学院药理学教研室,合肥,230032;安徽医科大学基础医学院药理学教研室,合肥,230032;安徽医科大学基础医学院药理学教研室,合肥,230032;安徽医科大学基础医学院药理学教研室,合肥,230032;安徽医科大学基础医学院药理学教研室,合肥,230032 |
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| 基金项目： | 安徽高等学校省级自然科学研究项目 |
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| 摘 要： | 目的 通过观察香术茯苓颗粒的镇痛和抗菌作用,探讨其治疗腹泻的可能机制. 方法 通过小鼠热板法和扭体法,观察香术茯苓颗粒的镇痛作用. 采用血清药理学和体外抗菌试验,观察香术茯苓颗粒的抗菌作用. 结果 香术茯苓颗粒3、6 g/kg给药3 d可延长小鼠疼痛潜伏期,减少冰醋酸引起的小鼠扭体次数,具有显著的镇痛作用;血清药理学实验显示,香术茯苓颗粒6 g/kg给药3 d血清可以增加大肠埃希菌抑菌圈直径,有明显的抑菌作用;但对伤寒杆菌和金黄色葡萄球菌无作用. 体外抗菌实验显示,香术茯苓颗粒对大肠埃希菌的最低抑菌浓度( MIC)为20. 0 mg/ml,最低杀菌浓度( MBC)为80. 0 mg/ml;对伤寒杆菌和金黄色葡萄球菌的MIC均为160. 0 mg/ml,未测出MBC值. 结论 香术茯苓颗粒具有一定的镇痛和抗菌作用,可能是其治疗腹泻的部分机制.
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| 关 键 词： | 香术茯苓颗粒 抗菌作用 镇痛作用 |
Analgesic and antibacteria effects of Ageratum rhizoma Atractylodis Tuckahoe granules |
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| Abstract: | Objective To study analgesic and antibacteria effects of Ageratum rhizoma Atractylodis Tuckahoe gran-ules ( ARTG) . Methods Hot-plate test and writhing test were used to study the analgesic effects of ARTG . Ser-um pharmacology and the antibacterial activity in vitro were used to study antibacteria effects of ARTG. Results ARTG(3,6 g/kg)administrated three days could increase the pain threshold in mice,decrease twist times induced by acetic acid. The serum pharmacology showed the serum of three days by ARTG(6 g/kg) had significally bacteri-ostatic effects against Escherichia coli. , but no effect on Typhoid bacillus and Staphylococcus aureus. In vitro, ARTG had certain bacteriostatic and bactericidal effects against Escherichia coli. , but no bactericidal effects against Typhoid bacillus and Staphylococcus aureus. Conclusion ARTG has analgesic and antibacteria effects in animal models,and they might be the part mechanism in treating diarrhea. |
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| Keywords: | Ageratum rhizoma Atractylodis Tuckahoe granules analgesic effect antibacteria effect |
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