Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study |
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Authors: | Luna B; Thulborn KR; Strojwas MH; McCurtain BJ; Berman RA; Genovese CR; Sweeney JA |
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Institution: | Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, PA, USA. lunab@msx.upmc.edu |
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Abstract: | Neurophysiological studies in non-human primates have identified
saccade-related neuronal activity in cortical regions including frontal
(FEF), supplementary (SEF) and parietal eye fields. Lesion and neuroimaging
studies suggest a generally homologous mapping of the oculomotor system in
humans; however, a detailed mapping of the precise anatomical location of
these functional regions has not yet been achieved. We investigated dorsal
frontal and parietal cortex during a saccade task vs. central fixation in
10 adult subjects using functional magnetic resonance imaging (fMRI). The
FEF were restricted to the precentral sulcus, and did not extend anteriorly
into Brodmann area 8, which has traditionally been viewed as their location
in humans. The SEF were located in cortex along the interhemispheric
fissure and extended minimally onto the dorsal cortical surface. Parietal
activation was seen in precuneus and along the intraparietal sulcus,
extending into both superior and inferior parietal lobules. These findings
localize areas in frontal and parietal cortex involved in saccade
generation in humans, and indicate significant differences from the macaque
monkey in both frontal and parietal cortex. These differences may have
functional implications for the roles these areas play in visuomotor
processes.
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