奥曲肽与奥美拉唑联合治疗老年消化性溃疡大出血疗效观察

目的 探讨奥曲肽联合奥美拉唑治疗老年人消化性溃疡伴大出血的效果。方法 将2011年1月～2013年3月在我院治疗的42例老年人消化性溃疡伴大出血患者作为观察组。同期39例老年人（对照1组）及66例〈60岁（对照2组）消化性溃疡伴大出血患者作为对照组。观察组予奥曲肽联合奥美拉唑进行治疗,对照组单独用奥美拉唑进行治疗。比较各组止血率、输血量及住院时间。结果 观察组72 h的止血率为92.9%,平均输血量（485.2±34.2）mL,住院时间（9.1±2.8）d,与对照1组比较,差异有统计学意义（P〈0.05）。结论 老年人消化性溃疡伴大出血使用奥曲肽联合奥美拉唑治疗止血效果更好。

The curative observation of the octreotide combined with omeprazole in treatment of elder patients with peptic ulcer following hemorrhage

Objective To investigate the efficacy of the combined treatment with octreotide and omeprazole for elderly patients with peptic ulcer following hemorrhage. Methods Forty-two elderly patients with peptic ulcer following hem- orrhage were treated as the observation group from January 2011 to March 2013. The contrast group were composed of 39 elderly patients with peptic ulcer following hemorrhage （contrast groupl） and 66 patients with peptic ulcer following hemorrhage whose ages were less than 60 years （contrast group2） in the same period. The patients in the observation group were treated with octreotide combined with omeprazole, while those in the contrast group were treated with omeprazole alone. The hemostasis rate and blood transfusion and the duration of hospitalization in each group was compared. Results The hemostasis rates during 72 hours were 92.9%, the average amount of blood transfusion was （485.2±34.2）mL, and the duration of hospitalization were （9.1±2.8） days in the observation group. The comparison between observation group and contrast group 1 had statistical significance（P 〈0.05）. Conclusion It has better effect on treat- ment of the elderly patients with peptic ulcer following hemorrhage with the method of octreotide combining with omeprazole.