三联疗法与序贯疗法在肝硬化高氨血症患者中根除幽门螺杆菌的疗效观察

目的 探讨肝硬化高氨血症患者采用三联疗法与序贯疗法根除Hp的效果观察。方法 选择肝硬化高氨血症并Hp感染阳性的患者共68例,随机分为三联根除组和序贯根除组。结果 两组的Hp根除率分别为79.4%（27/34）和85.3%（29/34）,差异无统计学意义（χ2=0.41,P〉0.05）。三联根除组治疗前与治疗后、治疗后1个月相比,血氨浓度下降显著（t分别为4.02、5.11,P均〈0.01）;序贯根除组治疗前与治疗后、治疗后1个月相比,血氨浓度亦下降显著（t=4.68、5.83,P均〈0.01）,但两组间血氨浓度同步下降的幅度均无统计学差异（P〉0.05）。结论 肝硬化高氨血症患者采用三联疗法与序贯疗法根除Hp的疗效无显著差异。

Efficacy of triple therapy and sequential therapy in the eradication of Helicobacter pylori in liver cirrhosis patients with hyperammonia

Objective To explore the efficacy of triple therapy and sequential therapy in the eradication of helicobacter pylori in liver cirrhosis patients with hyperammonia （Hp）. Methods A total of sixty-eight liver cirrhosis patients with hyperammonia and positive Hp infection were randomly divided into triple eradication group and sequential eradication group. Results The eradication rates of Hp in triple therapy group and sequential therapy group were 79.4% （27/34） and 85.3% （29/34） respectively. There was no significant difference between the two groups （x2=0.41, P〉0.05）. In the triple therapy group, the blood ammonia concentration of after treatment and one month after withdrawal of drugs de- creased significantly compared with before the treatment （t=4.02, 5.11, P〈0.01）.In the sequential therapy group, the blood ammonia concentration of after treatment and one month after withdrawal of drugs decreased significantly com- pared with before the treatment （t=4.68, 5.83, P〈0.01 ）.The fall of ammonia concentration was not statistical different between the two groups （P〉0.05）. Conclusion There is no significant difference in Hp eradication between triple therapy and sequential therapy in liver cirrhosis patients with hyperammonia.