| 四氯化碳诱导肝损伤的分子机制及中药干预的研究进展 |
| |
| 引用本文： | 尹连红,于浩,彭金咏. 四氯化碳诱导肝损伤的分子机制及中药干预的研究进展[J]. 中国现代应用药学, 2015, 32(9): 1147-1155 |
| |
| 作者姓名： | 尹连红 于浩 彭金咏 |
| |
| 作者单位： | 大连医科大学药学院，辽宁 大连 116044,大连医科大学药学院，辽宁 大连 116044,大连医科大学药学院，辽宁 大连 116044 |
| |
| 基金项目： | 国家自然科学基金(81274195)；辽宁省教育厅高等学校创新团队(LT2013019) |
| |
| 摘 要： | 目前，肝脏疾病已经成为威胁人类健康的常见疾病之一。四氯化碳(CC14)是一种常见的肝毒性化合物，可诱导急性肝损伤、肝纤维化、肝硬化和肝癌等肝脏疾病的发生。CC14诱导的肝损伤实验动物模型被广泛应用于保肝药物的筛选，且药理学研究发现许多中药对该类疾病具有良好的治疗作用。本文综述了近年来CC14诱导肝损伤的分子机制的研究进展和中药干预情况，为进一步阐明肝脏疾病发生、发展的内在机制及其预治提供依据。
|
| 关 键 词： | 四氯化碳；肝损伤；分子机制；中药干预 |
| 收稿时间： | 2014-12-26 |
| 修稿时间： | 2015-04-08 |
Molecular Mechanism and Intervention of Chinese Medicine of Carbon Tetrachloride Induced Liver Injury |
| |
| YIN Lianhong,YU Hao and PENG Jinyong. Molecular Mechanism and Intervention of Chinese Medicine of Carbon Tetrachloride Induced Liver Injury[J]. The Chinese Journal of Modern Applied Pharmacy, 2015, 32(9): 1147-1155 |
| |
| Authors: | YIN Lianhong YU Hao PENG Jinyong |
| |
| Affiliation: | College of Pharmacy, Dalian Medical University, Dalian 116044, China,College of Pharmacy, Dalian Medical University, Dalian 116044, China and College of Pharmacy, Dalian Medical University, Dalian 116044, China |
| |
| Abstract: | Liver disease has become one of the common diseases threatening human health. Carbon tetrachloride (CCl4) is a common compound for liver toxicity, which can induce liver diseases, such as acute liver injury, liver fibrosis, cirrhosis and liver cancer etc. Currently, the experimental animals with liver injury induced by CCl4 have been widely used for screening liver protection drugs. Pharmacological researches find that many Chinese medicines have therapeutic effect on the diseases. The research progress of molecular mechanism and intervention of Chinese medicines of liver injury induced by CCl4 are reviewed in this paper to provide a basis for clarifying the mechanism of liver disease and its prevention and treatment. |
| |
| Keywords: | carbon tetrachloride liver injury molecular mechanism intervention of Chinese medicine |
|
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
|
点击此处可从《中国现代应用药学》下载全文 |
|
