HSP70基因多态性对煤工尘肺遗传易感性的影响

目的探讨职业人群中HSP70基因对煤工尘肺遗传易感性的影响。方法随机选取河南省某煤矿的工人200例,其中100例胸片结果判定为0+的为病例组,100例胸片结果判定为正常的为对照组。采用PCR-RFLP方法检测两组观察对象中HSP70的基因型分布情况。结果病例组HSP70-1b2/b2基因型的频率明显高于对照组(χ2=8.26,P0.05),b2/b2基因型个体发生煤工尘肺的风险是b1/b1基因型个体的2.36倍(OR=2.36,95%CI=1.61～3.30);而HSP70-2和HSP70-hom的多态性在两组间差异无显著性。结论HSP70-1b2/b2基因型可能是煤工尘肺的一个易感基因型,存在该基因型的机体可能更容易罹患煤工尘肺。

Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker

Objective To explore the effect of heat shock protein 70(HSP70) gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker(CWP).Methods 100 workers whose sternites were assessed 0 + were chosen as the case group and 100 workers as the control.HSP70 genotypes were analyzed by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.Results There were significantly differences in HSP70-1 b2 /b2 genotype(χ2 = 8.26,P < 0.05) between the case group and the control,the risks of CWP in the individuals with b2 /b2 genotype were 2.36 times than those with b1 /b1 genotype.The polymorphism of HSP70-2 and HSP70-hom had no statistics significance in the difference of the two groups.Conclusion The results suggested that the individual with HSP70-1 b2 /b2 genotype may be a predisposing genotype to CWP and the individuals with the genotype could have weaker adaptability than the others.