Strain-specific development of the mossy fiber system in organotypic cultures of the mouse hippocampus |
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Authors: | H Schwegler B Heimrich F Keller P Renner W E Crusio |
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Affiliation: | Institut für Humangenetik and Anthropologie, Universit?t Heidelberg, F.R.G. |
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Abstract: | The postnatal development of the hippocampus of the inbred mice strains BALB/c, C57BL/6, and DBA/2 was studied in organotypic explant cultures using the roller-tube technique. In vivo, mice exhibit strain-specific mossy fiber distribution patterns. As a main result we found, that after cultivation of 3-4 weeks, similar strain-specific patterns became apparent in vitro, as visualized by a modified Timm staining. From this experiment we can conclude that a postnatal extrinsic influence cannot be the cause of the strain-specific hippocampal features. |
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