| 维拉帕米对硫唑嘌呤代谢物6-巯嘌呤药动学的影响 |
| |
| 引用本文： | 黄林清,周世文,周素琴,张诗平,汤建林,黄永平,邱磊. 维拉帕米对硫唑嘌呤代谢物6-巯嘌呤药动学的影响[J]. 华西药学杂志, 2001, 16(1): 31-33 |
| |
| 作者姓名： | 黄林清 周世文 周素琴 张诗平 汤建林 黄永平 邱磊 |
| |
| 作者单位： | 第三军医大学附属二院, |
| |
| 摘 要： | 目的：研究维拉帕米对硫唑嘌呤代谢物6－巯嘌呤药动学的影响。方法：采用高效液相色谱法（HPLC），以8只健康家兔为实验对象，对硫唑嘌呤单用与维拉帕米合用后血中硫唑嘌呤代谢物6－颈嘌呤浓度（6－MP）及药动学参数的变化进行观察。结果：合用维拉帕米后，6－MP的表观分布容积（Vd)增加3倍，AUC降低65．85，清除率(Cls)增加3倍，t1/2β延长1．5倍，其它药动学参数无显著影响，结论：结论拉帕米使硫唑嘌呤代谢物6－巯嘌呤的血药浓度明显主清除率明显增加。
|
| 关 键 词： | 维拉帕米 硫唑嘌呤 药代动力学 药物相互作用 |
| 文章编号： | 1006-0103(2001)01-0031-03 |
| 修稿时间： | 1999-12-01 |
EFFECT OF VERAPAMIL ON 6-MERCAPTOPURINE PHARMACOKINETICS IN RABBITS |
| |
| HUANG Lin-qing,Zhou Shi-Wen,ZHOU Su-qin,ZHANG Shi-ping,TANG Jian-lin,HUANG Yong-ping,QIU Lei. EFFECT OF VERAPAMIL ON 6-MERCAPTOPURINE PHARMACOKINETICS IN RABBITS[J]. West China Journal of Pharmaceutical Sciences, 2001, 16(1): 31-33 |
| |
| Authors: | HUANG Lin-qing Zhou Shi-Wen ZHOU Su-qin ZHANG Shi-ping TANG Jian-lin HUANG Yong-ping QIU Lei |
| |
| Abstract: | OBJECTIVE:To study effects of verapamil on 6-mercaptopurine pharmacokinetics. METHODS:Serum concentration of 6-mercaptopurine (6-MP) , a active metobilite of azathiopurine (Azp) , was determined by HPLC，and the pharmacokinetic parameters were researched after single administration of Azp and co-administration verapamil(Vp) in 8 rabbits.RESULTS:The results indicated that Vd and Cls of 6-MP increased 3 times , T1/2β raised 1.5 times , AUC decreased 65.8 percent , and other pharmacokinetic parameters have no significant differences after co-administration Vp in 8 rabbits.CONCLUSION:6-MP serum concentration was decreased and clearance rate increased evidently after co-administration verapamil in rabbits. |
| |
| Keywords: | Verapamil Azathioprine Pharmacokinetic Interaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
