宫颈分泌物MMP-8、IL-6检测对早产的预测价值研究

目的:研究宫颈分泌物基质金属蛋白酶-8(MMP-8)及白介素-6(IL-6)在早产患者的变化特点,探讨MMP-8、IL-6检测对早产的预测价值。方法:以117例先兆早产患者为先兆早产组,64例产检的正常孕妇为对照组,比较两组MMP-8、IL-6检测水平,并研究成功保胎患者与保胎失败患者MMP-8、IL-6水平差异,分析MMP-8、IL-6对早产诊断的方法学评价及相关性。结果:先兆早产MMP-8、IL-6水平均高于对照组(P<0.05);保胎失败组MMP-8、IL-6水平均高于保胎成功组(P<0.05);先兆早产组患者宫颈分泌物MMP-8、IL-6呈正相关(r=0.639,P<0.05);MMP-8对于早产诊断界值为20 ng/ml时,灵敏度85.5%、特异度85.9%,IL-6对于早产诊断界值为14 ng/ml时,灵敏度82.1%、特异度81.3%。结论:IL-6、MMP-8均与早产关系密切,对早产的诊断有一定预测价值。

Study on predictive values of MMP-8 and IL-6 detections in cervical secretions for premature delivery

Objective:To study the characteristics of changes of matrix metalloproteinase-8(MMP-8) and interleukin-6(IL-6) levels in cervical secretions of patients with premature delivery,and explore the predictive values of MMP-8 and IL-6 detections for premature delivery.Methods:A total of 117 patients with threatened premature labor were selected as threatened premature labor group,and 64 normal pregnant women receiving prenatal examination during the same period were selected as control group;the levels of MMP-8 and IL-6 in the two groups were compared,the differences of MMP-8 and IL-6 levels between the patients preventing miscarriage successfully and the miscarriage patients were studied,the methodological evaluation and correlation of MMP-8 and IL-6 for diagnosis of premature delivery were analyzed.Results:The levels of MMP-8 and IL-6 in threatened premature labor group were statistically significantly higher than those in control group(P<0.05);the levels of MMP-8 and IL-6 in miscarriage group were statistically significantly higher than those in non-miscarriage group(P<0.05);there was a positive correlation between MMP-8 level and IL-6 level in cervical secretions of threatened premature labor group(γ=0.639,P<0.05);when the threshold value of MMP-8 for diagnosis of premature delivery was 20 ng/ml,the sensitivity and specificity were 85.5% and 85.9%,respectively;when the threshold value of IL-6 for diagnosis of premature delivery was 14 ng/ml,the sensitivity and specificity were 82.1% and 81.3%,respectively.Conclusion:Both IL-6 and MMP-8 are correlated with premature delivery closely,which have a certain predictive values for diagnosing premature delivery.