脓毒症患者血清IL-6和NT—proBNP的变化及其临床意义

目的：探讨脓毒症患者白细胞介素-6（IL-6）和N末端前体脑钠肽（NT—proBNP）在脓毒症患者体内变化规律及临床意义。方法：选取2010—01—2011—12在我院ICU住院的脓毒症患者60例，脓毒症组根据28日生存与否分为生存组和死亡组，检测外周血IL-6和NT—proBNP的浓度。选取同期体检健康者50例为非脓毒症对照组，入院的24h内检测血清IL-6和NT-proBNP浓度。结果：与非脓毒症组比较，脓毒症组血清IL-6和NT—proBNP的浓度均明显升高（P〈O．01）；IL-6、NT—proBNP浓度、APACHEⅡ评分三者之间均呈正相关。与生存组比较，死亡组的血清IL-6和NT—proBNP的浓度均明显升高（均P〈0．01）。结论：脓毒症患者血清IL-6和NT-proBNP水平升高反映脓毒症的严重程度，与预后有较好的相关性。

The clinical significance of detecting the Interleukin 6 and NT-proBNP levels in serum in patients with sepsis

Objective：To investigate the variations and clinical significance of serum interleukin-6 （IL-6） and NT-proBNP levels in patients with sepsis. Method：Sixty sepsis patients with APACHE II scores greater than 12 were enrolled in the study. Fifty normal people were selected as controls. Patients in experimental group were di- vided into survival group and dead group according to 28-day mortality. The levels of serum IL-6 and NT-proBNP were detected and the correlations with APACHE II score were investigated. Result： In patients with sepsis, the av- erage level of serum IL-6 and NT-proBNP was significantly higher than that of the control group （P〈 0.01）. In patients with sepsis, there was a positive correlation between the IL-6 levels with the NT-proBNP （r=O1667,P= 0. 000）. The IL-6 levels were positively correlated with the APACHE lI score （r= 01485, P= 0. 000）, and the IL-6 levels were positively correlated with the NT-proBNP（r= 0. 741, P= 0. 000）. The II.-6 and NT-proBNP levels in serum in the dead group were higher than that of the survival group. Conclusion：The serum levels of IL-6 and NT- proBNP increased in patients with sepsis and there is a positive correlation between the IL-6, NT-proBNP levels with prognosis.