早产胎膜早破300例临床分析

目的:探讨胎膜早破(PROM)的原因、治疗方法、结局。方法:对2007年12月～2011年12月300例胎膜早破的住院分娩的产妇资料进行回顾性研究。结果:生殖道感染和胎位异常是胎膜早破发生的主要诱因;利托君、硫酸镁抑制宫缩治疗延长妊娠时间;糖皮质激素的应用减少了肺透明膜病变的发生率;血清C反应蛋白(CRP)的监测是抗生素应用时间、效果的指标;剖宫产指征主要是胎儿窘迫。结论:早产胎膜早破发生的原因与胎位异常及生殖道感染关系密切;抑制宫缩延长妊娠时间及抗生素、糖皮质激素的应用明显改善新生儿结局;分娩方式、时机主要依据胎儿宫内情况决定。

Clinical analysis on 300 cases with preterm premature rupture of membrane

Objective: To explore the causes,treatment and outcome of premature rupture of membrane(PROM).Methods: The data of 300 pregnant women with PROM who gave birth to their babies from December 2007 to December 2011 were studied retrospectively.Results: Reproductive tract infection and abnormal fetal position were main causes of PROM;ritodrine and magnesium sulfate could inhibit uterine contraction and prolong pregnancy time;application of corticosteroids reduced the incidence rate of pulmonary hyaline membrane disease;serum C-reactive protein(CRP) monitoring was a index of application time and effect of antibiotics;fetal distress was the main indication of cesarean section.Conclusion: The occurrence of PROM is closely related to abnormal fetal position and reproductive tract infection;inhibiting uterine contraction,prolonging pregnancy time,applications of antibiotics and glucocorticoids can obviously improve neonatal outcome;delivery modes and time mainly depend on intrauterine situations of fetus.