胺碘酮联合稳心颗粒治疗不稳定型心绞痛合并室性心律失常疗效及安全性对比

目的探究胺碘酮联合稳心颗粒治疗不稳定型心绞痛合并室性心律失常的疗效及安全性。方法以2009年1月—2012年5月该院收治的76例不稳定性心绞痛合并室性心律失常患者为研究对象,随机分成观察组和对照组,各38例。观察组和对照组均接受常规扩血管抗凝抗血小板治疗。观察组在常规治疗基础上加用胺碘酮和稳心颗粒,对照组在常规治疗基础上加用胺碘酮。观察对比两种治疗方案的疗效及安全性。结果治疗1个疗程后,观察组患者期间心绞痛发生次数、平均24 h内心肌缺血次数少于对照组,且累积硝酸甘油用量明显低于对照组,差异具有统计学意义(t=-8.497、-9.791、-7.836,P<0.05);观察组疗程以及随访期间室性早搏、室颤发生率明显低于对照组(χ2=4.145、5.029,P<0.05);观察组患者疗程以及随访期间部分不良反应发生率明显低于对照组(χ2=4.547、3.934,P<0.05)。结论相比于单纯使用胺碘酮,胺碘酮联合稳心颗粒的治疗方案可以显著降低患者心绞痛和部分室性心律失常发生次数,疗效优于单纯使用胺碘酮,不良反应少,具有更高的安全性,值得在临床实践中加以推广应用。

Efficacy and security of amiodarone combined with steady heart pellet in treating unstable angina associated with ventricular arrhythmias

Objective To investigate the efficacy and security of amiodarone combined with steady heart pellet in treating unstable angina associated with ventricular arrhythmias.Methods 76 cases of unstable angina patients associated with ventricular arrhythmias were selected as the study objects and randomly assigned into the observation group and the control group,each with 38 cases.The observation group was given the treatment of amiodarone combined with steady heart pellet based on the routine treatment,while the control group was given the treatment of amiodarone only.Results During the process of treatment,the times of angina occurrence,times of myocardial ischemia occurrence within 24h and cumulative doses of nitroglycerin of the observation group were significantly less than those of the control group（P 0.05）.The occurrence rate of premature ventricular contractions and VF of the observation group were significantly lower than those of the control group（P 0.05）.The numbers of some adverse reactions in the observation group were significantly less than those in the control group（P 0.05）.Conclusion Compared with amiodarone only,amiodarone combined with steady heart pellet can obviously decrease the occurrence times of unstable angina and part of ventricular arrhythmias and has higher security.It deserves to be promoted widely in the clinical treatment.