CD105和VEGF在水泡状胎块中的表达与意义

目的:研究CD105及VEGF在水泡状胎块与水肿性流产的绒毛滋养细胞中的表达差异及意义。方法:采用免疫组化SP法检测20例正常妊娠(NP),30例水肿性流产(HA),20例部分性水泡状胎块(PHM)和20例完全性水泡状胎块(CHM)患者绒毛滋养细胞中CD105和VEGF的表达水平。结果:①CD105在NP、HA、PHM和CHM中的阳性表达率分别是55.00%、36.67%、85.00%、95.00%,CD105在HM中阳性表达率明显高于HA和NP(P<0.05);②VEGF在NP、HA、PHM和CHM中的阳性表达率分别是50.00%、33.33%、25.00%、15.00%,VEGF在HM中阳性表达率低于HA和NP(P<0.05);③经Spearman等级相关检验,CD105和VEGF在HA与HM中表达呈负相关(r=-0.447,P<0.05)。结论:CD105和VEGF可作为标记绒毛滋养细胞的免疫组化标记物,用于水泡状胎块和水肿性流产的鉴别诊断。

Expressions and significances of CD105 and VEGF in hydatidiform mole

Objective:To explore the different expressions and significances of CD105 and vascular endothelial growth factor(VEGF) in villous trophoblasts between hydatidiform mole(HM) and hydropic abortus(HA).Methods:Immunohistochemical SP method was used to detect the expressions of CD105 and VEGF in villous trophoblasts of 20 cases with normal pregnancy(NP),30 cases with HA,20 cases with partial hydatidiform mole(PHM) and 20 cases with complete hydatidiform mole(CHM).Results:①The expressions of CD105 in NP,HA,PHM and CHM were 55%,36.7%,85% and 95%,respectively.The expression of CD105 in HM was significantly higher than that of HA and NP,the difference was statistically significant(P<0.05).②The expressions of VEGF in NP,HA,PHM and CHM were 50%,33.3%,25% and 15%,respectively.The expression of VEGF in HM was lower than that of HA and NP,the difference was statistically significant(P<0.05).③ The result of Spearman correlation test showed there was a negative correlation between expressions of CD105 and VEGF in HM and HA(r=-0.447,P<0.05).Conclusion:CD105 and VEGF can be used as immunohistochemcial markers of villous trophoblasts to differentiate diagnosis of HM and HA.