| XELIRI与FOLFIRI方案治疗晚期结直肠癌的临床对照研究 |
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| 引用本文： | 申凤乾,徐志巧,刘培杰,李宁,帖晓静,张燕. XELIRI与FOLFIRI方案治疗晚期结直肠癌的临床对照研究[J]. 中华肿瘤防治杂志, 2010, 17(5) |
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| 作者姓名： | 申凤乾 徐志巧 刘培杰 李宁 帖晓静 张燕 |
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| 作者单位： | 开封市第一人民医院肿瘤科,河南,开封,475000 |
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| 摘 要： | 为了评价XELIR方案和FOLFIRI方案对晚期结直肠癌近期疗效和毒副反应,对2006-07-08-2008-04-05接受XELIR化疗方案治疗的30例晚期结直肠癌患者进行回顾性分析,并与同期采用FOLFIRI化疗方案治疗的32例晚期结直肠癌患者比较,评价不同化疗方案的近期疗效和毒副反应。XELIR方案和FOLFIRI方案的总有效率分别为33.3%与34.4%,一线和二线有效率差异无统计学意义。XELIR组毒副反应以腹泻、手足综合征为主,FOLFI-RI组毒副反应以白细胞降低为主。初步研究结果显示,XELIR方案和FOLFIRI方案对晚期结直肠癌均有较好的临床疗效,化疗毒副反应有所不同,均可耐受。XELIR和FOLFIRI两种化疗方案均可作为晚期结直肠癌一或二线治疗方案。
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| 关 键 词： | 结直肠肿瘤 化疗 CPT-11 5-FU CF Capecitabine 叶酸 |
Comparison of efficacy and toxicity between XELIRI and FOLFIRI regimens for advanced colorectal cancer |
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| SHEN Feng-qian,XU Zhi-qiao,LIU Pei-jie,LI Ning,TIE Xiao-jing,ZHANG Yan. Comparison of efficacy and toxicity between XELIRI and FOLFIRI regimens for advanced colorectal cancer[J]. Chinese Journal of Cancer Prevention and Treatment, 2010, 17(5) |
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| Authors: | SHEN Feng-qian XU Zhi-qiao LIU Pei-jie LI Ning TIE Xiao-jing ZHANG Yan |
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| Affiliation: | SHEN+Feng-qian,XU+Zhi-qiao,LIU+Pei-jie,LI+Ning,TIE+Xiao-jing,ZHANG+Yan+Department+of+Oncology,First+People%5c's+Hospital+of+Kaifeng,Kaifeng+475000,P.R.China |
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| Abstract: | The objective of this study was to evaluate the efficacy and toxicity of irinotecan plus capecitabine(XELIRI regimen)compared with irinotecan plus 5-FU/LV(FOLFIRI regimen)in the treatment of advanced colorectal cancer.From July 8.2006 to April 5.2008,data of 30 patients with advanced colorectal cancer treated with XELIRI regimen was retrospectively analysed and compared with 32 patients treated with FOLFIRI regimen,to evaluate the efficacy and toxicity beteween them.The overall response rate of the XELIRI r... |
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| Keywords: | colorectal neoplasms chemotherapy irinotecan 5-Fluorouracil capecitabine Leucovorin |
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