腔内注入抗癌药治疗癌性积液疗效观察

本文报道我院自１９９０年１月～１９９５年２月，分别应用９种抗癌药，随机注入心包腔、胸、腹腔内治疗癌性积液５７例，进行疗效及毒性反应观察。结果：丝裂霉素（ＭＭＣ）加氟尿嘧啶（５－Ｆｕ），使用２例无效，喜树碱（ＯＰＴ）有效率２５％（１／４），噻替派（ＴＳＰＡ）有效率３３．３％（１／３），长春新碱（ＶＣＲ）有效率５４．５％（６／１１），短小棒状杆菌（ＣＰ）有效率６６．７％（２／３），顺铂（ＰＤＤ）有效率６０％（９／１５），卡铂（ＣＰ）有效率６６．７％（４／６），足叶乙甙（ＶＰ－１６）有效率９２．３％（１２／１３）。毒副作用轻，对造血机能、肝肾等没有重大损害。结果表明抗癌药能应用于腔内化疗，并能取得一定疗效。尤其是足叶乙甙，原为不能作腔内注射，国内外应用甚少，而今应用有效率最高，且安全，价格适中，值得推广。

Observe of the Effects on Treating Malignant Effusions when Anticancer Drugs are Injected into Cavities

This article is about the observation of curative effects and poisonous reactions in treating malignant effusions of 57 cases when 9 kinds of anticancer drugs were injected seperatelyinto the pericardium cavity, thoracic and abdominal cavities according to circumstances fromJanuary of 1990 to February of 1995 in our hospital. As a result, two cases by using MMCplus 5-Fu failed. The effective rates of the drugs used were as follows. The effective rate ofOPT was 25% (1/4),TSPA was 33. 3% (1/3),VCR was 54. 5% (6/11), CP was 66. 7%(2/3), PDD was 60%(9/15), CP was 66. 7% (4/6), and VP-16 was 92. 3% (12/13). Thepoisonous side effect was light. There was no serious damage to the functions of hemo-topoiesis, the liver and the kidnes. The results indicsted that anticancer drugs could be applied to cavities for chemitheraoy and gained certain curative effects. Especially VP-16, having been considered not to be injected into the cavities, and seldom applied at home andabroad, now get the highest applicable effective rate. It is safe, moderatc. in prices, andworth spreading the use.