Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083 |
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| Authors: | Ui Hideaki Shiomi Kazuro Suzuki Hideaki Hatano Hiroko Morimoto Hiromi Yamaguchi Yuichi Masuma Rokuro Sunazuka Toshiaki Shimamura Hiroyuki Sakamoto Kimitoshi Kita Kiyoshi Miyoshi Hideto Tomoda Hiroshi Omura Satoshi |
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| Affiliation: | Kitasato Institute for Life Sciences and Graduate School of Infectious Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan. |
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| Abstract: | A new NADH-fumarate reductase inhibitor, verticipyrone, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1083. The structure was established as (E)-2-methoxy-3,5-dimethyl-6-(3-methyl-2-undecenyl)-4H-pyran-4-one. Verticipyrone exhibited an IC50 value of 0.88 nM against NADH-fumarate reductase of Ascaris suum. Verticipyrone inhibited both Ascaris and bovine heart complex I, and its synthetic analogue, 8,9-dihydro-8-hydroxyverticipyrone, showed good selectivity against Ascaris complex I. |
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