| 肝细胞癌中EMS1蛋白的表达 |
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| 引用本文： | 李晓杰,胡玉林,谢志斌,谢海龙. 肝细胞癌中EMS1蛋白的表达[J]. 临床与实验病理学杂志, 2008, 24(2): 188-190 |
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| 作者姓名： | 李晓杰 胡玉林 谢志斌 谢海龙 |
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| 作者单位： | 湖南省郴州市第一人民医院病理科,郴州,423000;南华大学肿瘤研究所,衡阳,421001;湖南省郴州市第一人民医院病理科,郴州,423000;南华大学肿瘤研究所,衡阳,421001 |
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| 摘 要： | 目的 探讨EMS1蛋白表达与肝癌发生、发展及临床病理特征的关系.方法 采用免疫组化SP法,对78例肝癌组织、其中68例附癌旁肝组织和8例正常肝组织中EMS1蛋白表达进行检测.结果 EMS1蛋白表达定位于细胞的胞质,着色呈黄色至棕黄色.肝癌中阳性表达率89.69%,高于癌旁及正常肝组织30.26%(P＜0.001);无肝硬化肝癌阳性表达率73.91%,低于伴有肝硬化95.56% (P＜0.05);伴静脉内癌栓组94.12%与无静脉内癌栓组70.59%差异有显著性 (P＜0.05);随着组织分级的增高(分化程度的降低),阳性表达率明显增高,其差异有显著性 (P＜0.05);而与性别、年龄、肿瘤大小无关.结论 EMS1蛋白高表达与肝癌发生、肝硬化、静脉内癌栓及组织学分级相关.
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| 关 键 词： | 肝肿瘤 肝细胞癌 EMS1蛋白 免疫组织化学 |
| 文章编号： | 1001-7399(2008)02-0188-03 |
| 修稿时间： | 2007-09-16 |
Expression of EMS1 protein in hepatocelluar carcinoma |
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| LI Xiao-jie,HU Yu-lin,XIE Zhi-bing,XIE Hai-long. Expression of EMS1 protein in hepatocelluar carcinoma[J]. Chinese Journal of Clinical and Experimental Pathology, 2008, 24(2): 188-190 |
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| Authors: | LI Xiao-jie HU Yu-lin XIE Zhi-bing XIE Hai-long |
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| Abstract: | Purpose To study the relationship between the expression of EMS1 gene and carcinogenesis, invasion and metastasis. Methods EMS1 protein expression in 78 cases of hepatocellular carcinoma (HCC) and 8 cases of normal liver tissues was examined by SP immunohistochemical method. Results EMS1 protein displayed in cytoplasmic localization. The positive rate of EMS1 protein expression was 89.69% in HCC. The positive rate of EMS1 protein expression was 30.26% in their corresponding paracancerous tissues and normal ... |
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| Keywords: | hepatocelluar carcinoma EMS1 protein immunohistochemistry |
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