Impact of waist/height ratio on insulin resistance and function of pancreatic β-cells in newly diagnosed Type 2 diabetes mellitus

Objective To study the impact of central obesity on insulin resistance and the function of pancreaticβcells in newly diagnosed Type 2 diabetes. Methods Eighty-six type 2 diabetes mellitus (T2DM) patients were divided into 2 groups according to their waist to hip ratio. Metabolic parameters and Insulin resistance and the function of pancreatic β-cells were compared. Insulin resistance were calculated by HOMA-IR and the function of pancreatic β-cells were detected by HOMA-βand ISF-Arg. Results HOMA-IR index, HOMA-IS and ISF-Arg in WHR ≥0.85 (male) or 0.80 (female) group were significantly higher than that of WHR ＜ 0. 85 (male) or 0. 80 (female) group ( P ＜ 0. 01 ), whereas WHR ＜ 0. 85 (male) or 0. 8 ( female ) group had significantly higher fasting sugar levels and HbA1c and favorable lipid profile (P ＜ 0.05 ). Conclusion WHR is an useful parameter in roughly judging the function of β-cell and insulin resistance.