分泌性中耳炎中耳积液嗜酸细胞阳离子蛋白与IgE测定

目的：通过测量分泌性中耳炎（OME）患者中耳积液中嗜酸细胞阳离子蛋白（MECP）、中耳积液IgE（MIgE）及血ECP（SECP）的含量，进一步探讨OME发病机制与变态反应的关系。方法：对31例OME患者，用Uni-CAP-100型变应原体外检测系统分别测量MECP、MIgE及SECP含量，得出结果并统计学处理。结果：31例OME患者检测到MECP均值为56．88μg／L，明显升高9例，占28．1％；MIgE均值为27．2ku／L，明显升高3例，占9．7％。MECP与MIgE呈正相关（P〈0．05）；SECP均值为5．6μg／L。结论：ECP存在于OME的鼓室积液中，部分OME是中耳的局限性变态反应炎性过程。OME发病过程中存在着复杂的变态反应机制。

The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion

OBJECTIVE: To study the relationship between otitis media of effusion (OME) and allergy by investigating eosinophil cationic protein in middle ear effusion ( MECP), middle ear effusion IgE (MIgE) and serum eosinophil cationic protein (SECP). METHOD: The specimens drawn from 31 patients of OME were tested with Uni-CAP-100 allergic antigen testing system for the MECP, IgE and SECP. The results then were analyzed by statistical methods. RESULT: MECP were found in all the effusion specimens of 31 patients, the average concentration of which was 56.88 microg/L. The MECP concentration level in nine specimens (28.1%) was significantly elevated. The average concentration of MIgE was 27.2 ku/L. The MIgE concentration level in three specimens (9.7%) was remarkably increased. There was a positive correlation between the MECP level and the MIgE level( P <0.05). The average concentration of SECP was 5.6 microg/L. CONCLUSION: ECP exists in the middle ear effusion of OME. OME is an allergic inflammatory process more localized in middle ear itself in some patients. There may be a complicated allergic mechanism in OME.