Typing of pneumococcal surface protein A (PspA) in Streptococcus pneumoniae isolated during epidemiological surveillance in Brazil: towards novel pneumococcal protein vaccines |
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Authors: | Brandileone Maria Cristina C Andrade Ana Lucia S S Teles Elaine M Zanella Rosemeire C Yara Teresa I Di Fabio José Luis Hollingshead Susan K |
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Affiliation: | Bacteriology Branch, Adolfo Lutz Institute (IAL), Secretary of Health of the State of S?o Paulo, CEP: 01246-902, SP, Brazil. brandi@ial.sp.gov.br |
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Abstract: | Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer broad range of protection against different strains. We have investigated the frequency of PspA family 1 (Fam1) and family 2 (Fam2) proteins among Streptococcus pneumoniae recovered from ongoing surveillance in Brazil. Fam1 and Fam2 were expressed in comparable rates among 366 isolates, with the potential coverage of 94.3%. PspA families were not associated to age group or source of isolates. However, considering the significant tendency of increasing prevalence of Fam2 associated to widespread dissemination of the genetically-related resistant strains, the monitoring of the PspA families derived from population-based data may be necessary in the context of vaccine development. |
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