血糖调节异常者血脂代谢的初步研究

目的初步评价血糖调节受损患者血脂代谢异常情况。方法检测糖耐量正常(NGT)、单纯空腹血糖异常(IFG)、单纯糖耐量异常(IGT)、空腹血糖异常合并糖耐量异常(IFG IGT)和糖尿病(DM)患者空腹血糖和餐后2 h血糖及空腹血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A-I(apo A-I)和载脂蛋白B(apo B)水平,计算非高密度脂蛋白胆固醇(non-HDL-C)和血浆致动脉硬化指数(AIP),比较各组间血清脂质成分的差异。结果IFG组血清TC、LDL-C、non-HDL-C和apo B水平较NGT组明显升高(P<0.01),而TG、HDL-C、AIP差异无统计学意义(P>0.05)。IGT组血清TC、TG、LDL-C、non-HDL-C、apo A-I、apo B和AIP水平较NGT组显著升高(P<0.01),前6项指标与IFG IGT组差异无统计学意义(P>0.05)。IFG IGT组与NGT组比较,各指标差异均有统计学意义(P<0.01);HDL-C、non-HDL-C和AIP水平与IFG组比较差异有统计学意义(P<0.01)。DM组表现出典型的DM性脂代谢紊乱伴AIP水平显著异常。non-HDL-C和apo B间存在良好的相关性(P<0.01)。结论血糖调节受损者不同程度的存在血脂代谢异常,主要表现为TC、TG、LDL-C、non-HDL-C和apo B水平的升高和HDL-C、apo A-I的降低,伴不同程度AIP水平的改变。

The study on the lipid metabolism in the impaired glucose regulation subjects

Objective To evaluate the changes of lipid profile in the subjects with impaired glucose regulation. Methods The levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apoprotein A-I(apo A-I),apoprotein B(apo B) fasting plasma glucose(FPG) and 2 h plasma glucose in including normal glucose tolerance(NGT) group,impaired fasting glucose(IFG) group,impaired glucose tolerance(IGT) group,IFG IGT group and diabetes mellitus(DM) patients was detected.The non-HDL-C and atherogeric index of plasma(AIP) were counted in these groups.The difference of the lipid profile between the groups was evaluated. Results The levels of TC,LDL-C,non-HDL-C and apo B in IFG group were increased significantly than in NGT group.The levels of TC,TG,LDL-C,non-HDL-C,apo A-I, apo B and AIP in IGT group were increased significantly than in NGT group(P<0.01).The AIP in IGT group was different with that in IFG IGT group(P<0.01).The indexes in IFG IGT group was different with that in NGT group(P<0.01).The levels of HDL-C,non-HDL-C and AIP in the IFG IGT group was different with that in the IFG group(P<0.01).The dyslipidemia and AIP were significantly different in DM.There was a good relativity between non-HDL-C and apo B. Conclusions The impaired lipid metabolism in the impaired glucose regulation subjects is a common problem.The dyslipidemia includes the higher level in TC,TG,LDL-C,non-HDL-C and apo B,the lower level in HDL-C and apo A-I,and the abnormal AIP level in the impaired glucose regulation subjects.