|
|||||
|
|
Capsule 13C-urea breath test for the diagnosis of Helicobacter pylori infection |
|
| Authors: | Peng Nan-Jing Lai Kwok-Hung Liu Ren-Shyan Lee Shui-Cheng Tsay Daw-Guey Lo Ching-Chu Tseng Huei-Hwa Huang Wen-Keui Lo Gin-Ho Hsu Ping-I |
| Affiliation: | 1. Department of Nuclear Medicine,Kaohsiung Veterans General Hospital,Kaohsiung,Taiwan,China 2. Division of Gastroenterology,Department of Internal Medicine,Kaohsiung Veterans General Hospital,Kaohsiung,Taiwan,China 3. Department of Nuclear Medicine,Taipei Veterans General Hospital and National Yang-Ming University,Taipei,Taiwan,China 4. Institute of Nuclear Energy Research,Taoyuan,Taiwan,China 5. Department of Pathology and Laboratory Medicine,Kaohsiung Veterans General Hospital,Kaohsiung,Taiwan,China |
| Abstract: | AIM: To compare the accuracy of capsule 13C-urea breath test (UBT) with conventional invasive methods for the diagnosis of Helicobacter pylori infection. METHODS: One hundred patients received CLO test, histological examination, culture and 100- or 50-mg capsule UBT for the diagnosis of H pylori infection. H pylori infection was defined as those with positive culture or positive results from both histology and CLO test. RESULTS: Both the sensitivity and specificity of the 100-mg capsule UBT (n=50) were 100%. The sensitivity and specificity of the 50-mg capsule UBT (n = 50) were 96.4 and 100%, respectively. Taken together, the accuracy of capsule UBT (n =100) was higher than that of CLO test, histology and culture (100% vs 92%, 91% and 89%, respectively; P= 0.035, 0.018 and 0.005, respectively). Our data showed that the optimal timing of sampling for 100-and 50-mg capsule UBT was 15-30 and 6-15 min, respectively. CONCLUSION: Capsule UBT has a higher accuracy compared with biopsy-based tests. It is an ideal method for the diagnosis of H pylori infection. |
| Keywords: | 13C-urea breath test Capsule Helicobacter pylori Oral urease |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |