高密度脂蛋白胆固醇和冠心病的相关性研究

目的:探讨高密度脂蛋白胆固醇水平与冠心病的相关性.方法:选择427例经冠状动脉造影证实的冠心病患者作为病例组,并选择同期住院的冠脉造影结果阴性的306例非冠心病患者作为对照组,测定两组患者的血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白LP(a)等指标进行比较分析.结果:冠心病组与对照组比较,HDL-C水平显著降低(P＜0.05);在冠心病组中随着冠状动脉病变支数的增加,HDL-C逐渐下降(P＜0.05).多元Logistic回归分析,低HDL-C水平为冠心病的独立危险因素.结论:HDL-C与冠心病发生发展及冠脉病变程度呈显著负相关.TC/HDL-C可能对冠心病的诊断具有更好的预测价值.

Relationship between high density lipoprotein cholesterol and coronary heart disease

Objective: To investigate the relationship between high density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD). Methods: A total of 427 CHD patients diagnosed by coronary angiography were selected as cases, and 306 non-CHD patients admitted to the hospital in the same period were selected as controls. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),apolipoproteinA1(ApoA1), apolipoprotein B (ApoB), lipoprotein (a)(LP(a)), and free fatty acids ( FFA) were determined and analyzed. Results: The levels of HDL-C in CHD group were significantly lower than that in non-CHD group (P＜0.05). In CHD group, HDL-C decreased gradually as the number of coronary artery disease branch increased (P＜0.05). Logistic multiple regression analysis,showed low HDL-C level was an independent risk factor for coronary heart disease. Conclusion: HDL-C show significantly negative correlation to the incidence,development and severity of coronary heart disease. TC / HDL-C may have a better predictive value in coronary heart disease diagnosis.