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调冲消癥方治疗乳腺增生病63例
引用本文:孙巧云. 调冲消癥方治疗乳腺增生病63例[J]. 中国实验方剂学杂志, 2015, 21(4): 197-201
作者姓名:孙巧云
作者单位:山东即墨市人民医院, 山东 即墨 266200
摘    要:目的:探讨调冲消癥方治疗乳腺增生病的临床疗效及内分泌与血管活性因子的影响。方法:将126例乳腺增生病患者采用随机数字法分为对照组和观察组各63例。对照组服用乳癖散结胶囊,4粒/次,3次/d,内服;观察组采用调冲消癥方,每天1剂。两组疗程均为12周。进行治疗前后疼痛、肿块评分;检测治疗前后雌二醇(E2),泌乳素(PRL),孕酮(P),睾酮(T),血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子(b FGF)含量,进行治疗前后乳腺钼靶X射线片检测,对有效患者进行6个月的随访观察记录复发情况。结果:观察组疾病疗效优于对照组(P<0.05);经Ridit分析,观察组钼靶X射线摄影疗效优于对照组(P<0.05);治疗后观察组乳房疼痛、乳房触痛、肿块硬度、肿块分布范围及肿块大小评分均低于对照组(P<0.01);治疗后观察组E2和PRL水平低于对照组(P<0.01),P水平高于对照组(P<0.01);治疗后观察组血清VEGF和b FGF水平低于对照组(P<0.01);观察组复发率为27.12%低于对照组的47.06%(P<0.05)。结论:调冲消癥方内服治疗乳腺增生病能减轻患者疼痛,软化、缩小肿块,并能降低复发率,临床疗效优于乳癖散结胶囊,其作用机制可能与调节内分泌,抑制血管生成因子有关。

关 键 词:乳腺增生病  调冲消癥方  内分泌  血管内皮生长因子  碱性成纤维细胞生长因子
收稿时间:2014-10-17

Effect of Tiaochong Xiaozheng Decoction in Treating 63 Cases with Mammary Gland Hyperplasia Disease
SUN Qiao-yun. Effect of Tiaochong Xiaozheng Decoction in Treating 63 Cases with Mammary Gland Hyperplasia Disease[J]. China Journal of Experimental Traditional Medical Formulae, 2015, 21(4): 197-201
Authors:SUN Qiao-yun
Affiliation:People's Hospital of Jimo City in Shandong Province, Jimo 266200, China
Abstract:Objective: To discuss the curative efficacy of Tiaochong Xiaozheng decoction in treating hyperplasia of mammary glands and to investigate its influence on endocrinology and endothelin. Method: One hundred and twenty-six patients with hyperplasia of mammary glands were randomly divided into the control group (63 cases) and the observation group (63 cases) by a random number table. Patients in the control group received 4 grains Rubi Sanjie capsules thrice daily. Patients in the observation group received Tiaochong 1 dose Xiaozheng decoction once daily. All patients in two groups received 12 weeks of treatment. Before and after treatment, scores of pain and mass were graded. Contents of estrogen (E2), prolactin (PRL), progesterone (P), testosterone (T), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were detected. Molybdenum target X-ray was detected, and relapse constitution of patients who had curative efficacy was recorded during the 6-month follow-up. Result: The curative efficacy in the observation group was superior to that in the observation group (P<0.05). X-ray molybdenum target photography effect in the observation group was better than that in the control group by ridit analysis (P<0.05). Scores of breast pain, breast tenderness, lump hardness, mass distribution and lump size in the observation group were less than those in the control group after therapy (P<0.01). Levels of E2 and PRL in the observation group were lower than those in the control group (P<0.01), while the P level was higher than that in the control group (P<0.01). After treatment, serum VEGF and bFGF levels in the observation group were lower to those in the control group (P<0.01). The recurrence rate in the observation group was 27.12%, which was less than 47.06% in the control group (P<0.05). Conclusion: Tiaochong Xiaozheng decoction could reduce pain feeling, soften and narrow the mass, and reduce the recurrence rate with mammary gland hyperplasia disease. Its clinical curative effect is obviously distinct. Its mechanism may be related to regulating endocrine and inhibiting angiogenesis factor.
Keywords:mammary gland hyperplasia disease  Tiaochong Xiaozheng decoction  endocrine  vascular endothelial growth factor  basic fibroblast growth factor
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