B7-H1在恶性肿瘤中的表达进展

B7-H1(B7 homolog 1)是免疫调节分子B7家族的一个成员，主要分布在心脏、胎盘、肺、脾、淋巴结、胸腺、肾、骨骼肌和胎肝组织中。B7-H1在多种肿瘤细胞上广泛高表达，它与免疫细胞上的程序性死亡分子 1结合后，启动caspase级联反应诱导免疫细胞的凋亡，导致肿瘤免疫逃逸的发生。近年来，有关B7-H1在某一恶性肿瘤中的表达以及它与临床病理、预后和免疫学因素的相关性报道诸多。作者通过总结分析近年来的相关文献，对B7-H1在一些常见恶性肿瘤中的表达进展作一综述。

Progress of B7-H1 expression in malignant tumors

B7 homolog 1 (B7-H1), a member of B7 family of immunoregulatory molecule, was widely expressed in cells and organs, including heart, placenta, lung, spleen, lymph node, thymus, kidney, skeletal muscle, as well as fetal hepatic tissues. Also, it is highly expressed in tumor cells. It could be apoptosis of immunocytes through triggering the caspase cascade reaction by combining with programmed death-1 (PD-1), which finally resulted in tumor immune escape. Recently, extensive studies have been conducted to investigate its expression in malignant tumor, and its association with clinicopathological, prognostic and immunological factors. In this review, we summarized the expression of B7-H1 in common malignant tumors.