Rho/Rho激酶信号通路与低氧所致肺纤维化

小G蛋白Rho参与了细胞黏附、迁移、生长、细胞收缩及细胞分裂等多种生物学行为.近来研究显示Rho/Rho激酶信号通路的异常活化参与了肺部疾病的发生,如肺动脉高压和肺纤维化.低氧作为一种潜在的促纤维化因素主要通过促内皮细胞凋亡、血管生成及炎症反应的调节来参与纤维化的发生.且Rho/Rho激酶信号通路与低氧所致肺纤维化的过程中所涉及主要细胞因子都有着直接或IhJ接的关系.因此,本文就Rho/Rho激酶信号通路的生物学特征及其与低氧致肺纤维化过程中细胞凶子的关系作一综述.

Rho/Rho-kinase mediated signaling and hypoxia-induced pulmonary fibrosis

Small GTPase Rho participates in many biological behaviour such as cell adhesion,migration,growth,cell contraction and cytokinesis. Abnormal activation of the Rho/Rho-kinase pathway hasbeen shown to play a role in lung diseases such as pulmonary artery hypertension and pulmonary fibrosis.Hypoxia,as a potential flbrotic stimulus, participates in fibrosis through induction of epithelial cell apoptosis,angiogenesis,and modulation of inflammatory reaction. Rho/Rho-kinase mediated signaling has a direct or indirect relationship with the major cytokines which are involved in the process of hypoxia-induced pulmonary fibrosis. This review summarizes the biological characteristics of the Rho/Rho-kinase mediated signaling and the relation with the major cytokines in the process of hypoxia-induced pulmonary fibrosis.