Synthesis and cytotoxicity of novel chrysin derivatives |
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Authors: | Kun Hu Wei Wang Hong Cheng ShaSha Pan Jie Ren |
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Affiliation: | (1) Faculty of Chemistry & Chemical Engineering, Jiangsu Polytechnic University, Changzhou, 213164, People’s Republic of China |
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Abstract: | A series of chrysin derivatives 8a–8v were prepared and tested in vitro against HCT-116 (human colon cancer cell line), Hela (human cervical carcinoma cell line), DU-145 (human prostate cell line), K562 (human leukemia cell line), and SGC-7901 (human gastric cancer cell line). The chemical structures of these compounds were confirmed by means of MS, IR, 1H NMR, 13C NMR, and elemental analysis. Among these derivatives, 7-(2-(piperazin-1-yl)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one, 8n, had the strongest activity against HCT-116, Hela, DU-145, K562, and SGC-7901 cells. . |
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