胰岛素样生长因子-1与妊娠期高血压疾病的相关性研究

目的探讨胰岛素样生长因子-1（IGF-1）与妊娠期高血压疾病发病的关系。方法选取30例妊娠期高血压疾病患者（疾病组）及10例同期住院待产正常孕妇（对照组）血清及胎盘标本，采用放射免疫方法（RIA）检测两组血清中IGF-1浓度水平，采用免疫组织化学SABC法检测IGF-1在两组胎盘中的表达情况。结果疾病组IGF-1水平明显低于对照组且随着疾病的严重程度增加而降低；疾病组与对照组胎盘组织IGF-1表达部位无差异，在疾病组表达明显降低。胎盘IGF-1表达强度与血清IGF-1水平存在直线正相关。结论胰岛素样生长因子-1参与妊娠期高血压疾病发病。

Relationship between insulin-growth factor-1 and the hypertensive disorder complicating pregnanc

Objective： To study changes of levels of IGF-1 in maternal serum and IGF-1 expression of placenta in hypertensive disorder complicating pregnancy and the clinical significance. Methods： This study included 30 women with hypertensive disorder complicating pregnancy （study group） and 10 women with nomal pregnancy （control group）. Radioimmunoassay （RIA） was used to measure Level of IGF-1. The localization of IGF-1 protein was analyzed using immunohistochemical staining. SPSS 11.5 was used, P 〈0.05 was considered statistically significant. Results ： Level of IGF-1 in maternal serum in study group was significantly reduced compared with that in control group （ P〈0.05 ） ; The expression of IGF-1 protein was significantly decreased in study group compared with uncomplicated case in term placentas （ P〈0.05 ）. Conclusion： IGF-1 in serum may involve in the progression of hypertensive disorder complicating pregnancy.