肺癌患者肿瘤M_2型丙酮酸激酶的表达水平及其临床意义

目的：探讨肿瘤M2型丙酮酸激酶（tumor M2pyruvate kinase,TuM2-PK））在肺癌患者血中的表达水平及其临床应用价值。方法：用ELISA法分别检测68例肺癌、42例良性肺疾病患者和77名健康体检者血浆中的TuM2-PK表达水平,并进行比较分析。结果：TuM2-PK在肺癌组阳性率73.53%,肺良性病变组11.90%,健康对照组15.58%,肺癌组明显高于后两组（P〈0.01）,有淋巴结转移患者TuM2-PK阳性率（82.61%）高于无淋巴结转移患者（P〈0.05）。结论：TuM2-PK对肺癌的辅助诊断有较高的临床价值,并对判断淋巴结转移及临床治疗具有一定的指导意义。

The clinical significance of tumor type M_2 pyruvate kinase level in patients with lung cancer

Objective：To investigate the expression and diagnostic value of tumor M2-PK in lung cancer.Methods：The tevel of tumor M2-PK in plasma was detected by ELISA in 68 lung cancer patients,42 lung benign lesion patients and 77 health controls.Results：TuM2-PK tevel in plasma and the positive rate were singificanfly higher in lung cancer（73.53%）than that in benign lung disease and in health controls（11.90%and 15.58%）（P0.01）,TuM2-PK level was higher in lung cancer patients with lymph node metastasis（82.61%）than those without metastasis（P0.05）.Conclusion：The measurement of TuM2-PK is of great clinical value for the diagnosis of lung cancer,and is helpful in the evaluation of lymph node metastasis.