肠道胃肠间质瘤的临床病理改变

目的：了解肠道胃肠间质瘤（gastrintestinal stromal tumors GIST）的特殊临床病理改变。方法：收集31例肠道胃肠间质瘤的临床病理资料,每例常规光镜切片观察,作免疫组化CD34、CD117、SMA、S100、CKp标记。结果：肠道胃肠间质瘤临床症状以腹痛、肿块、便血为主。分布在十二指肠、小肠和直肠。以高危险度胃肠间质瘤为主。免疫组化标记：肿瘤细胞以CD34和CD117阳性为主。结论：肠道胃肠间质瘤临床症状与肠恶性肿瘤相似,诊断依据组织学改变和免疫组化标记,并以此判断肿瘤的危险度。

Clinicopatholgic study of gastrointestinal stromal tumor in intestine

Objective：To investigate the clinicopatholgic feature of gastrointestinal stromal tumors（GISTs） in intestine.Methods： In addition to light microscopic observations,immunohistochemical assays of CD34,CD117,SMA,S100 and CKp were used.Results： In 31 cases,five cases were at very low risk-low risk（VLR-LR）,2 cases immediat risk（IR） and 24 cases high risk（HR） of GISTs in intestines.The GISTS of intestines showed spindle cell type in most specimens.CD117 and CD34 were positive in most cases.Conclusion： The symptoms of GISTS in intestines were similar as intestine carcinoma.Pathologic features were different in the level of GISTS risk of intestine.The results showed that undifferentiation type constitutes the largest category in GISTs of intestine.