| 放射治疗对直肠癌组织中肿瘤转移抑制基因Kiss-1表达的影响 |
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| 引用本文： | 柯春林,林素勇,陈绍勤,戴起宝,涂明美. 放射治疗对直肠癌组织中肿瘤转移抑制基因Kiss-1表达的影响[J]. 陕西肿瘤医学, 2011, 0(6): 1151-1152 |
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| 作者姓名： | 柯春林 林素勇 陈绍勤 戴起宝 涂明美 |
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| 作者单位： | [1]福建医科大学附属第一医院放疗科,福建福州350005 [2]福建医科大学附属第一医院胃肠外科,福建福州350005 |
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| 基金项目： | 福建省卫生厅青年科研课题（编号：2009-2-12）; 福建省自然科学基金项目（编号：2008J02074） |
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| 摘 要： | 目的：探讨放射治疗对直肠癌组织中Kiss-1基因表达的影响及意义。方法：应用免疫组化SP法检测29例放射治疗前、后直肠癌组织中Kiss-1基因的表达,通过图像分析系统（Image-Pro Plus 6.0）进行定量分析。结果：放射治疗前直肠癌组织中Kiss-1基因表达水平的图像分析灰度值为160.81±2.78,放疗后为158.04±3.24,差异无统计学意义（P〉0.05）。结论：放射治疗对直肠癌中肿瘤转移抑制基因Kiss-1的表达无明显影响,推测放射治疗不会增加直肠癌转移的风险。
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| 关 键 词： | 直肠癌 放射 Kiss-1 转移 免疫组化 |
The influence of radiotherapy on expression of metastasis suppressor gene Kiss-1 in human rectal carcinoma |
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| KE Chun-lin,LIN Su-yong,CHEN Shao-qin,DAI Qi-bao,TU Ming-mei. The influence of radiotherapy on expression of metastasis suppressor gene Kiss-1 in human rectal carcinoma[J]. Shaanxi Oncology Medicine, 2011, 0(6): 1151-1152 |
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| Authors: | KE Chun-lin LIN Su-yong CHEN Shao-qin DAI Qi-bao TU Ming-mei |
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| Affiliation: | 1Department of Radiation Oncology;2Department of Gastrointestinal Surgery,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China. |
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| Abstract: | Objective：To investigate the effects of radiation on metastasis suppressor gene Kiss-1 expression of rectal carcinoma.Methods：The expression of Kiss-1 was examined immunohistochemically with SP method in 29 specimens of rectal carcinoma tissues before radiation and after radiation by Image analyse system（Image-Pro Plus 6.0）.Results：The expression of Kiss-1 gene in rectal carcinoma before radiation was 160.81±2.78,and after radiation was 158.04±3.24,（P0.05）.Conclusion：Radiation did not affect the expression of Kiss-1 gene in rectal cacinoma,and radiotherapy did not increase the risk of rectal cancer metastasis. |
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| Keywords: | rectal carcinoma radiation Kiss1 metastase immunohistochemistry |
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