Caveolin-1在肝细胞肝癌中的表达及意义

目的：研究Caveolin-1（Cav-1）在肝细胞肝癌（HCC）中的表达及其与临床病理参数、预后之间的关系。方法：利用免疫组化方法检测160例HCC组织中Cav-1的表达情况,并分析其与临床病理参数和预后的关系。结果：160例肝癌标本中,65例（41%）标本为Cav-1阴性,95例（59%）标本为Cav-1阳性。肝癌组织Cav-1阳性细胞表现出典型的细胞膜表达。单因素分析结果显示Cav-1在HCC癌组织的表达与肿瘤的分化、门静脉侵犯、肝内转移和复发有关,差异均具有统计学意义（P〈0.05）;K-M生存曲线显示Cav-1阴性表达组生存率高于Cav-1阳性表达组,差异具有统计学意义（P〈0.001）。多因素COX逐步回归分析结果显示Cav-1是总体生存率（P=0.047）的独立因素。结论：Cav-1在HCC中的过表达,对HCC的发生、发展、侵袭转移及预后可能起重要作用。

Clinical significance of Caveolin-1 in hepatocellular carcinoma

Objective：To study the clinical significance of Caveolin-1（Cav-1）in hepatocellular carcinoma.Methods：One hundred and sixty cases of hepatocellular carcinoma were tested for expression of Cav-1 by SP immunohistochemistry.Results： Out of 160 HCC samples,65（41%）were negative for Caveolin-1,95（59%） were positive.The Cav-1-positive cells in HCC tissues showed unequivocal cytoplasmic staining pattern.The positive rate of Cav-1 expression was significantly correlated with histological differentiation,portal venous invasion,intrahepatic metastasis and recurrence（P0.05）.K-M survival curve showed the survival rate was significantly lower in the positive expression of the Cav-1 patients compared to the negative ones（P0.001）.The Multivariate COX proportional hazards model analysis also showed that the expression of Cav-1 was an independent predictor of overall survival（P=0.047）.Conclusion： Cav-1 may play an important role in the development and metastasis of hepatocellular cancer.