宫腺肌病恶变3例临床病理分析

目的：探讨子宫腺肌病恶变病例的临床病理特点。方法：回顾性分析我院2001年1月至2010年12月收治的3例子宫腺肌病恶变患者的临床病理资料。结果：3例患者就诊年龄为45、56及58岁,临床表现主要为经量增多、经期延长、绝经后阴道流血及盆腔痛,3者血清CA125浓度分别为34.98U/ml、196.6U/ml、22.4U/ml,超声检查无特异性,均依靠术后石蜡病理确诊,3例患者均行手术治疗,术后酌情辅以放化疗。结论：子宫腺肌病恶变罕见,术后病理为唯一确诊依据,术前诊断困难,易误诊、漏诊,为治疗方式的选择及实施造成一定局限性,应提高对该病的认识,重视早期诊断,正确治疗,改善预后。

Clinicopathologic characteristics of 3 malignant transforming of adenomyosis

Objective：To investigate the clinicopathologic characteristics of malignant transforming of adenomyosis.Methods： A retrospective analysis was performed on 3 cases that diagnosed in our hospital during January 2001-December 2010.Results： The age of 3 patients were 45,56 and 58 years.The most common presenting symptoms were hypermenorrhea,menstruation,postmenopausal bleeding and deep dyspareunia.Serum CA125 levels were 34.98 U/ml,196.6 U/ml and 22.4 U/ml,and ultrasound were not specific.Only pathology can make up the diognosis.The treatment method was operation plus irradiation,or operation plus chemotherapy.Conclusion： Malignant transformation of adenomyosis is not exceptional disease,preoperative diagnosis is difficult,easer for misdiagnose.We should improve our knowledge for its early diagnosis,good intervention.