C-12多肿瘤标志物蛋白芯片检测系统在肺癌诊断中的价值

目的：评价C-12多肿瘤标志物蛋白芯片检测系统在肺癌中的诊断价值。方法：采用C-12多肿瘤标志物蛋白芯片检测系统检测67例肺癌患者、69例肺良性病变患者和70例健康对照者血清中12种标志物（CAl99、NSE、CEA、CA242、Ferritin、Beta—HCG、AFP、Free—PSA、PSA、CAl25、HGH、CAl53）的水平。结果：肺癌组阳性率（79．10％）显著高于肺部良性病变组（30．43％）及对照组（18．57％）阳性率（P〈0．01）。其中CEA、CAl25、NSE、CAl99、CA242项肿瘤标志物的水平和阳性率显著高于肺部良性病变组和对照组（P〈0．05）。CEA阳性率以腺癌组最高，NSE以小细胞肺癌组最高。结论：C-12多肿瘤标志物蛋白芯片检测系统对提高肺癌诊断率有较高的临床价值。CEA、CAl25、NSE、CAl99、CA242联合检测是一种既经济又有效的诊断组合，而且对病情监测有一定应用价值。

Diagnostic value of C - 12 multi - tumor markers protein biochip detection system in lung cancer

Objective：To evaluate the diagnostic value of C - 12 multi - tumor markers protein biochip detection system （ C - 12 ） in lung cancer. Methods ： The serum levels of 12 tumor makers （ CA199, NSE, CEA, CA242, Ferritin, Beta - HCG, AFP, Free - PSA, PSA, CA125, HGH, CA153 ） were detected in 67 cases with lung cancer （ cancer group） and 69 cases with pulmonary benign diseases （benign group） and 70 healthy persons （control group） by C - 12. Results： The positive rates were 79.10% ,30.43% and 18.57% in lung cancer, pulmonary benign diseases and healthy groups respectively. There was significantly higher positive rate in cancer group than those in the benign group and the control group（P 〈0.01 ）. The positive rates of CEA ,CA125 ,NSE,CA199 and CA242 in cancer group were significantly different compared with those in the benign group and control group （ P 〈 0.05 ）. Positive rate of CEA was the highest in lung adenocarcinoma than others, while positive rate of NSE was the highest in small cell lung cancer than others. Conclusion： The early clinic diagnosis rate of lung cancer can be improved by the application of C -12 in lung cancer, and the combined tests of CEA, CA125, NSE, CA199 and CA242 are more economic and effec- tive for lung cancer diagnosing, which also provide value for monitoring the cancer progress.