肿瘤免疫逃逸机制的研究新进展

目的：探讨肿瘤免疫逃逸的机制,指导肿瘤治疗理论研究。方法：应用NCBI的PubMed文献数据库,以＂肿瘤免疫逃逸、T淋巴细胞、髓源性抑制性细胞,免疫抑制因子,胸腺萎缩＂等为关键词,检索2005至2010相关文献。最后纳入分析40余篇文献。结果：肿瘤细胞可通过多种途径逃避机体免疫系统的监视,包括肿瘤对T淋巴细胞的功能抑制,诱导分化出免疫抑制细胞如髓源性抑制细胞,调节性T细胞等。同时肿瘤可导致免疫抑制因子如IL-10,IL-4、TGF-β、VEGF、IDO、COX-2的上调。促进免疫器官胸腺的萎缩。结论：肿瘤免疫逃避机制十分复杂,深刻认识肿瘤免疫逃逸机制,有助于肿瘤防治研究的深入。

Current progress of the mechanism of tumor immune escape

Objective：To explore the mechanism of tumor immune escape.Methods： The papers published from 2005 to 2010 were retrieved from PubMed of NCBI on the Key words：tumor,immune escapes,thymus atrophy,lymphocyte etc and 40 papers were analyzed.Results：Tumor can adopt different mechanisms of immune escapes,including impairment of T lymphocyte function,induction of immune suppressive cells such as myeloid-derived suppressor cells and regulatory T cells.Meanwhile tumor can increase the level of immunosuppressive factors such as IL-10,IL-4,TGF-β,VEGF,IDO,COX-2 and cause atrophy of thymus.Conclusion：The mechanism of tumor immune escape is very complicated.A better understanding of the underlying mechanism will lead to more effective immunotherapy study.