豫西地区胃黏膜不典型增生和肠化生的临床流行病学调查

目的：探讨近4年豫西地区胃黏膜不典型增生和肠化生的相关临床流行病学资料的特点及变化趋势。方法：选取2007年1月-2010年6月我院胃镜室行内镜检查的21932例患者为研究对象,对胃黏膜不典型增生和肠化生患者的一般临床资料和病理资料进行回顾性分析。结果：胃黏膜不典型增生和不典型增生伴肠化生有随年龄增加检出率增高的趋势,且不典型增生程度随年龄增加而程度增高。重度不典型增生≥60岁患者比例高于轻、中度不典型增生,（P〈0.05）,中度不典型增生≥60岁患者比例高于轻度不典型增生;中度肠化生≥60岁患者比例高于轻度肠化生患者（P〈0.05）。贲门部不典型增生和肠化生中≥60岁患者比例高于胃角和胃体部（P〈0.05）,幽门螺杆菌检出率均较单纯慢性浅表性胃炎组高,（P〈0.05）差异有统计学意义。结论：胃黏膜不典型增生和肠化生的发生与年龄和幽门螺杆菌感染有关,常发生于贲门部。

Clinical investigation of gastric epithelial dysplasia and intestinal metaplasia in Western Yu Region,China

Objective：To explore the clinical epidemiologic characteristics and tendency of gastric epithelial dysplasia and intestinal metaplasia in Western Yu region.Methods：The clinical data of 21932 patients by gastroscopy were collected from 2007 to 2010,the clinical and pathology data of gastric epithelial dysplasia and intestinal metaplasia were analyzed retrospectively.Results：Age,at which dysplasia and dysplasia accompanied with intestinal metaplasia could be deteced,showed an increasing trend.The degree of dysplasia was related to age.The percentage of patients who were above 60 years of age in severe dysplasia was much higer than that in mild and moderate dysplasia（P0.05）,and in moderate dysplasia was much higher than mild dysplasia（P0.05）.The proportion of patients who were above 60 years of age was significantly greater in moderate intestinal metaplasia compared with that in mild intestinal metaplasia.The proporation of patients who were above 60 years of age was significantly higher in the gastric cardia than that in gastric corpus and gastric incisura.The detection of Hp in gastric epithelial dysplasia and intestinal metaplasia was higher than in chronic superficial gastritis.Conclusion：Gastric epithelial dysplasia and intestinal metaplasia was related with age and Helicobacter pylori and it mostly located on the gastric cardia.