老年早期非小细胞肺癌三维适形放疗的临床分析

目的：观察老年早期非小细胞肺癌患者三维适形放疗的疗效。方法：2002年到2007年,采用三维适形放疗治疗35例老年早期非小细胞肺癌,放疗剂量66-80Gy,中位剂量70Gy,常规分割,2.0Gy/d,年龄71-89岁,中位年龄76岁,其中12例≥80岁。Ⅰ期患者13例,Ⅱ期22例。结果：治疗有效率23例（65.7%）。3年总生存率为28%,中位生存时间38.9个月;3年肿瘤相关生存率为39%,中位生存时间43.5个月。1例（2.9%）患者死于放疗导致的晚期放射性肺损伤,没有观察到其他严重的放疗毒性发生。结论：采用三维适形放疗技术治疗老年早期非小细胞肺癌是安全有效的。

Three-dimensional conformal radiotherapy in elderly with early stage non-small cell lung cancer

Objective：To investigated the effectiveness of three-dimensional conformal radiotherapy（3D-CRT） alone in elderly patients with early stage（I/II）non-small cell lung cancer（NSCLC）.Methods：Between 2002 and 2007,a total of 35 elderly with early stage NSCLC patients were treated by 3DCRT.Radiotherapy doses ranged 6680 Gy（median,70 Gy） using standard fractionation（2.0 Gy per fraction）.The age range was 71-89 years（median 76 years） 12 patients ≥80 years old.There were 13（37.1%） stage I and 22（62.9%） stage II patients.Results：Radiographic objective response rate was observed in 23（65.7%） patients.The median survival time was 38.9 months and 3-year survival time was 28%,while the median cancer-related survival time was 43.5 months and a 3-year cancer-related survival rate was 39%.One（2.9%） patient died of RT-induced late lung toxicity,no other high-grade toxicity was observed during this study.Conclusion： 3D-CRT alone was effective and low toxic in elderly with early stage（I/II） NSCLC.