乳腺肿瘤CD44V6的表达及意义

目的：探讨乳腺肿瘤中CD44V6（细胞粘附分子44变异体6）的表达及其与乳腺良恶性肿瘤、乳腺癌淋巴结转移和预后的关系。方法：免疫组化检测90例乳腺癌（淋巴结转移阳性45例,阴性45例）和20例乳腺纤维腺瘤中CD44V6的表达,分析CD44V6的表达与乳腺肿瘤良恶性的鉴别、乳腺癌患者淋巴结转移及预后的关系。结果：乳腺癌组CD44V6阳性表达率为71.1%,显著高于乳腺纤维腺瘤组15%;伴淋巴结转移组CD44V6阳性表达率为88.9%,显著高于无淋巴结转移组53.3%;不同病理分型乳腺癌中CD44V6阳性表达率差异无统计学意义;不同临床分期和生存期乳腺癌中CD44V6的阳性表达率显著不同。结论：CD44V6在乳腺良恶性肿瘤的鉴别、乳腺癌淋巴结转移与否的判断和预后评估等方面有一定意义。

Expression and significance of CD44V6 in breast tumor

Objective：To investigate the expression of CD44V6 in breast tumor and its significance.Methods：The expression of CD44V6 in 90 breast carcinoma tissues（45 with lymph node metastasis,other 45 without） and 20 fibroadenoma of breast were studied by immunochemical envison methods.Results：Positive expression of CD44V6 in breast carcinoma was 75.6%,significantly higher than fibroadenoma of breast.Positive expression of CD44V6 in breast carcinoma with lymph node involvement was 88.9%,significantly higher than breast carcinoma without lymph node involvement;In different pathocategory,the positive expression of CD44V6 was not significantly different.In different clinical stage and different life span the positive expression of CD44V6 was significantly different.Conclusion：CD44V6 can be regarded as valuable molecular marker to distinguish benign from malignant tumor,lymph node metastasis or not and to estimate the prognosis.