p53基因在骨肉瘤中的表达及其临床意义 |
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引用本文: | 张世权,肖德明,朱玉华,关弘,李伟,谭纪锋. p53基因在骨肉瘤中的表达及其临床意义[J]. 陕西肿瘤医学, 2011, 0(1): 145-146 |
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作者姓名: | 张世权 肖德明 朱玉华 关弘 李伟 谭纪锋 |
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作者单位: | [1]深圳第二人民医院骨科,广东深圳518035 [2]深圳第二人民医院病理科,广东深圳518035 |
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摘 要: | 目的:探讨p53基因在骨肉瘤组织中的表达及其临床意义。方法:应用免疫组化方法(s—P法)测定p53蛋白在36例骨肉瘤和17例骨软骨瘤组织中的表达,并随访骨肉瘤患者生存时间。36例骨肉瘤中男19例,女17例,年龄平均19.9岁。Enneking分期II,3例,Ⅱ,27例,Ⅲ,6例,并发病理性骨折7例。结果-36例骨肉瘤随访时间平均3年6个月,其中存活3年及以上者13例,存活3年以下者23例,死亡病例均因骨肉瘤远处转移全身衰竭致死。36例骨肉瘤p53蛋白阳性表达率为52.8%,显著高于骨软骨瘤组,有显著性差异(P〈0.01)。p53蛋白表达在不同Enneking外科分期组间无显著性差异(P〉0.05),在生存时间3年以上组及3年以下组间有显著性差异(P〈0.01)。结论:p53基因突变对骨肉瘤的发病可能产生影响,对患者预后评估具有一定价值。
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关 键 词: | 骨肉瘤 p53蛋白 免疫组化 |
Protein expression of p53 in osteosarcoma and the correlation with clinical features and prognosis |
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Affiliation: | ZHANG Shi - quan ,XIAO De - ming ,ZHU Yu - hua ,GUAN Hon ,LI Wei ,TAN Ji - feng ( Department of Orthopeadics ;2 Depatrment of Pathdogy the Second People& Hospital of Shenzhen , Shenzhen 518035, China.) |
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Abstract: | Objective:To explore the protein expression of P53 in osteosarcoma and its relationship with clinical features and prognosis. Methods: The protein expression of P53 was detected by using immunohistochemistry (LSAB) in 36 cases of osteosarcoma and 17 cases of osteochondroma, proved by surgery and pathology, and the sur- vival time in 36 cases of osteosarcoma were followed - up. Results : All 36 cases of osteosarcoma were followed - up with the average time of 42 months ,there were 13 cases survival more than 36 months, the positive expression rate of p53 was 52.8% in 36 cases of osteosarcoma, and higher than in osteochondroma , (P 〈0.01 ). the positive expres- sion rate of p53 was higher in 23 cases survival less than 36 months. Conclusion:Threr is a definite relationship between p53 and osteosarcoma, p53 is useful for the assessment of the prognosis of osteosareoma. |
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Keywords: | oteosarcoma p3 imunohistochemistry pognosis |
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