体部伽玛刀治疗中晚期胰腺癌156例临床疗效观察

目的：观察体部伽玛刀治疗中晚期胰腺癌的临床疗效。方法：对156例中晚期胰腺癌,采用体部伽玛刀治疗。根据病灶的形状,大小及患者的身体状况,确定治疗次数及分次剂量,取50%-60%的等剂量曲线覆盖靶区,单次剂量300-450CGY,治疗10-14次,每日一次,总剂量4000-4500CGY。结果：治疗结束后2-6月CT复查156例,肿瘤完全缓解20例（12.8%）,部分缓解114例（73.1%）,稳定16例（10.3%）,进展6例（3.8%）,治疗后随访生存6月138例（88.5%）,生存12月63例（40.4%）,24月以后生存18例（11.5%）。体部伽玛刀治疗未见穿孔、大出血、持续高热等严重并发症。结论：体部伽玛刀治疗中晚期胰腺癌临床疗效较好,是一种安全、可靠的治疗方法,为临床医生提供了一种新的治疗手段。

Clinical therapeutic effectiveness of body r-knife in 156 patients with advanced pancreatic carcinoma

Objective：To investigate the clinical therapeutic effectiveness of body r-knife in patients with advanced pancreatic carcinoma.Methods： One hundred and fifty-six patients with advanced pancreatic carcinoma were treated with body r-knife therapy.The dosage distribution and other radiotherapeutic plans were established on the basis of carcinoma position.The isodose carve was 50%-60% and covered the target volume The single dose was 350-450cGy.The radiation was performed once everyday for 10-14time.Results： Among 156 patients who received CT after 2 to 6months of the therapy,20 cases achieved complete response and 114 cases achieved partial response,remained unchanged in16 patients,and enlarged in 6 patients,the 6-month,12month,24-month overall survival rates were 88.5,40.4 and 11.5.No perforation serious bleeding or continuous high fever was observed.Conclusion： Body r-knife can achieve a high local control rate and survival rate.Its clinical therapeutic effectiveness is satisfactory.Body r-knife is a safe and reliable treatment option for patients with locally advanced pancreatic carcinoma.