Immunohistochemical expression of p16 protein in oral squamous cell carcinoma and lichen planus |
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| Institution: | 1. Dental Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran;3. Oral and Maxillofacial Diseases Research Center, Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Community Medicine and Public Health, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Pathology, National University Hospital, Singapore;3. Department of Pathology and Laboratory Medicine, University of Indiana School of Medicine, IN, USA;4. Clarient Laboratories, Alisio Viejo, CA, USA;5. Department of Pathology, Cornell University School of Medicine, New York, NY, USA;1. Thoracic Oncology Research Group, Multidisciplinary Thoracic Oncology Program, Baptist Cancer Center, Memphis, TN;2. Division of Epidemiology and Biostatistics, School of Public Health, University of Memphis, Memphis, TN;3. Trumbull Laboratories, LLC/Pathology Group of the Mid-South, Memphis, TN;1. St. Erik Eye Hospital, Stockholm, Sweden;2. Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden;3. Department of Clinical Pathology, Örebro University Hospital, Örebro, Sweden;1. General Hospital of Guadalajara Hospital civil antiguo de Guadalajara Jalisco, Guadalajara, Mexico;2. Laboratory of Pathology, National Institute of Rehabilitation, México City, Mexico;3. Neurological Center, Department of Clinical Neurophysiology, The American British Cowdray Hospital, Mexico City, Mexico;4. Department of Neuropathology, National Institute of Neurology and Neurosurgery, México City, Mexico;1. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI;2. Department of Radiology, Medical College of Wisconsin, Milwaukee, WI |
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| Abstract: | Epithelial carcinogenesis is a multistep process. Specific genetic events lead to malignant transformation of oral epithelium. Oral squamous cell carcinoma (OSCC) may be preceded by potentially malignant lesions such as oral lichen planus (OLP). The p16 protein functions as a negative regulator of the cell cycle progression. Altered pattern of p16 serves as a biomarker for oral mucosal dysplasia and malignant growth. The purpose of this study was to evaluate p16 expression in OSCC and OLP to determine whether it can be a useful marker for early detection of carcinogenesis. We examined p16 expression in 45 OSCCs (15 grade I, 15 grade II, and 15 grade III), 15 OLPs without dysplasia, and 8 normal mucosal specimens with immunohistochemistry. p16 was interpreted as positive if more than 70% of tumor cells showed brown nuclear and cytoplasmic staining. All of the OSCC and control group samples showed negative immunoreactivity, whereas 26.7% of OLP samples were positive for p16. Our findings suggest that p16 expression could not be used as a helpful marker for detection of development toward malignancy in OLP samples. |
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