Measuring Apparent Trabecular Structure With pQCT: A Comparison With HR-pQCT |
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| Affiliation: | 1. Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada;2. Toronto Rehabilitation Institute–University Health Network, Lyndhurst Centre, Toronto, ON, Canada;3. Department of Medicine and Medical Imaging, University of Toronto, Toronto, ON, Canada;4. University Health Network, Toronto, ON, Canada;5. Department of Civil Engineering, McMaster University, Hamilton, ON, Canada;6. Department of Radiology, McMaster University, Hamilton, ON, Canada;7. Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;1. Laboratoire de Physiologie et des Explorations Fonctionnelles, Université de Sousse, Faculté de Médecine Ibn Eljazzar, Sousse, Tunisia;2. Service de Rhumatologie, CHU Farhat Hached, Sousse, Tunisia;1. Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada;2. Bariatric Surgery, McGill University Health Center, Montreal, QC, Canada;1. Department of Family Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan;2. Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK;3. Osteoporosis Treatment Centre, Kuala Lumpur, Malaysia;4. SCBR (Saitama Center for Bone Research), Kubojima Clinic, Saitama, Japan;5. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia;6. Department of Radiology, Peking Union Medical College Hospital Beijing, Beijing, China;7. Department of Medicine, University of Santo Tomas Hospital, Manila, Philippines;8. Division of Endocrinology, Department of Medicine, National University Health System, Singapore;9. Obstetrician and Gynecologist in Beijing United Family Hospital, Beijing, China;10. Seoul National University College of Medicine, Seoul, Korea;11. Jakarta Osteoporosis Center, Jakarta, Indonesia;12. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;13. Osteoporosis Center, Taiwan Adventist Hospital, Taipei, Taiwan;14. Department of Nuclear Medicine and Radiology, Lin Shin Hospital, Taichung, Taiwan;15. Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan;16. Division of Endocrinology and Metabolism, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan;17. Division of Rheumatology & Allergy, Vanderbilt University Medical Center, Nashville, TN, USA;18. Center of Bone Diseases, Department of Bone & Joint, Lausanne University Hospital, Lausanne, Switzerland;19. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK;20. Secction of Family Medicine, Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, Douliou City, Taiwan;21. Department of Orthopedics, National Taiwan University Hospital, Taipei, Taiwan;1. Children''s Hospital Los Angeles, Los Angeles, CA;2. Cincinnati Children''s Hospital Medical Center, Cincinnati, OH;3. Children''s Hospital of Philadelphia, Philadelphia, PA;4. Creighton University, Omaha, NE;5. Columbia University, New York, NY;6. University of California, San Francisco, San Francisco, CA;7. National Institute of Child Health and Human Development, Bethesda, MD;1. College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;2. Saskatoon Osteoporosis Centre, Saskatoon, Saskatchewan, Canada;1. Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, IL, USA;2. Queens Diabetes and Endocrinology Associates, Flushing, NY, USA |
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| Abstract: | We evaluated how comparable peripheral quantitative computed tomography (pQCT) measurements of cortical thickness, density, and apparent trabecular structure at the ultradistal tibia were with those measured with high-resolution pQCT (HR-pQCT). We also examined whether the accuracy of the pQCT-based trabecular and cortical measurements improved with reductions in slice thickness from the standard 2.2 mm to 1.1 and 0.6 mm. We immersed 15 dry tibia specimens in saline in a sealed cylinder and scanned 22.5 mm from the distal tibia plateau using pQCT and HR-pQCT. pQCT underestimated cortical thickness by Stratec (CThStratec) and trabecular spacing (Tb.Sp) by 21.4% and 72.9%, whereas bone volume to total volume (BV/TV) and cortical density (CDen) were overestimated by 265.8% and 13.1%, respectively. Measurements of trabecular volumetric bone mineral density, trabecular area, total area, cortical thickness by custom software were comparable, but for CThStratec, Tb.Sp, BV/TV, and CDen, the differences between imaging devices varied with magnitude of the estimate. We recommend that researchers or clinicians interested in using pQCT to measure apparent trabecular structure or cortical thickness at the epiphyses, or in comparing findings from different devices, be aware of the differences between HR-pQCT and pQCT. |
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