强脉冲光联合Nd:YAG激光治疗黄褐斑疗效观察

目的:探讨强脉冲光联合Nd:YAG激光治疗黄褐斑的疗效。方法:60例患者按治疗方法不同分成3组:强脉冲光组、Nd:YAG激光组、联合组（强脉冲光联合Nd:YAG激光组），每组20例患者，观察3组患者疗效和副作用。结果:3组之间疗效两两比较采用Mann-Whitney秩和检验，强脉冲光组和激光组疗效无显著差异，而联合组疗效显著好于强脉冲光组（Z=7.123, P=0.024）和激光组（Z=6.024, P=0.030）。3组患者治疗后均无出现色素沉着加重、色素脱失病等不良反应。强脉冲光组和激光组的满意度无显著差异，而联合组的满意度显著好于强脉冲光组（Z=7.361, P=0.029）和激光组（Z=6.831, P=0.027）。结论:强脉冲光联合Nd:YAG激光治疗黄褐斑是一种安全有效的治疗方法，值得临床推广。

Therapeutic efficacy of intense pulsed light combined with Nd:YAG laser for treatment of chloasma

Abstract: Objective To investigate the clinical efficacy of intense pulsed light combined with Nd:YAG laser in the treatment of melasma. Methods According to different treatment methods, 60 patients were divided into 3 groups, namely intense pulsed light group, Nd:YAG laser group and combined treatment group (intense pulsed light combined with Nd:YAG laser group), with 20 patients in each group. The therapeutic efficacies and side effects of 3 groups were observed. Results The results of Mann-Whitney rank sum test for pairwise comparison on therapeutic efficacy showed that there was no significant difference between intense pulsed light group and laser group, and that the therapeutic efficacy of combined treatment group was significantly higher than that of intense pulsed light group (Z=7.123, P=0.024) and laser group (Z=6.024, P=0.030). All 60 patients had no adverse reactions such as aggravation of pigmentation and depigmentation disease. No significant difference was found in the degree of satisfaction between intense pulsed light group and laser group, but the degree of satisfaction of combined treatment group was significantly higher than that of the intense pulsed light group (Z=7.361, P=0.029) and laser group (Z=6.831, P=0.027). Conclusion Intense pulse light combined with Nd:YAG laser which is a safe and effective treatment method for melasma is worthy of clinical promotion.