Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women |
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| Affiliation: | 1. Department of Epidemiology, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, IA 52242, United States;2. Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, United States;3. Department of Public Health Sciences, University of California at Davis, Med Sci 1C, Davis, CA, United States;4. Department of Preventive Medicine, University of Tennessee Health Science Center, 600 Jefferson Avenue, Memphis, TN 38105, United States;5. Medstar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Research, 6525 Belcrest Road #700, Hyattsville, MD, United States;6. Department of Epidemiology, University of California, Box 951740, 27-138 CHS, Los Angeles, CA 90095, United States;7. Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR 97227, United States;8. Department of Family, Community and Rural Health, The Commonwealth Medical College, Medical Sciences Building, Room 1013, 525 Pine Street, Scranton, PA 18509, United States;9. John A. Burns School of Medicine and Cardiovascular Division, University of Hawaii, The Queens Medical Center, 1301 Punchbowl Street, Honolulu, HI 96813, United States;10. Department of Internal Medicine, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, United States |
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| Abstract: | AimThe objective of this study is to examine the relationship between self-reported birth weight and the adult occurrence of type 2 diabetes mellitus in a large multi-ethnic population of women.MethodsBaseline data from the Women's Health Initiative Observational Study [n = 75,993] was used to examine the association between participant birth weight category and prevalent type 2 diabetes mellitus. Models were adjusted for age, ethnicity, body mass index and other pertinent risk factors. Sub-analyses were performed stratifying by ethnicity.ResultsThere was a strong inverse association between birth weight and type 2 diabetes mellitus with a birth weight of <6 pounds (lbs) (OR: 1.16, 95% CI: 1.01, 1.33) significantly associated with an increased risk of type 2 diabetes mellitus and a birth weight of ≥10 lbs (OR: 0.72, 95% CI: 0.57, 0.92) associated with a decreased risk of type 2 diabetes mellitus compared to women who reported their birth weight between 7 and 8 lbs 15 ounces (oz). Stratifying by ethnicity, the inverse association between birth weight and type 2 diabetes mellitus was only apparent in White women, but not Black, Hispanic or Asian women.ConclusionLower birth weight was associated with increased T2D risk in American White and Black post-menopausal women. |
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| Keywords: | Birth weight Diabetes Fetal programming |
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