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Intraparenchymal pulmonary lipoma: pathologic-radiologic correlation of a rare presentation of a common neoplasm
Affiliation:1. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI;2. Department of Radiology, Medical College of Wisconsin, Milwaukee, WI;1. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Pathology, National University Hospital, Singapore;3. Department of Pathology and Laboratory Medicine, University of Indiana School of Medicine, IN, USA;4. Clarient Laboratories, Alisio Viejo, CA, USA;5. Department of Pathology, Cornell University School of Medicine, New York, NY, USA;1. Division Measure, Model & Manage Bioresponses, Department of Biosystems, KU Leuven, Kasteelpark Arenberg 30, B-3001 Leuven, Belgium;2. Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium;1. Thoracic Oncology Research Group, Multidisciplinary Thoracic Oncology Program, Baptist Cancer Center, Memphis, TN;2. Division of Epidemiology and Biostatistics, School of Public Health, University of Memphis, Memphis, TN;3. Trumbull Laboratories, LLC/Pathology Group of the Mid-South, Memphis, TN
Abstract:We report a rare case of pulmonary intraparenchymal lipoma. Lipomas are benign adipocytic tumors, which are ubiquitous in distribution, particularly in the subcutis and soft tissue. Visceral lipomas, in particular, pulmonary lipomas, are rarely reported. Even rarer are intraparenchymal lipomas, such as this case, of which less than 10 have been reported in the medical literature. The radiologic (computed tomographic scan) findings of pulmonary lipoma may be somewhat difficult to evaluate. In this case, on initial review, the computed tomographic findings were not diagnostic, but retrospective analysis revealed attenuation values suggestive of an adipocytic lesion. A high index of suspicion and careful attention to attenuation values are therefore required for radiologic diagnosis. Excision is necessary for histologic confirmation, which is generally relatively straight forward, although admixture with fibrous tissue and some cytologic atypia may pose diagnostic challenges.
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