Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes |
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Institution: | 1. Department of Medical and Health Sciences, Division of Community Medicine, Linköping University, 581 83 Linköping, Sweden;2. Department of Clinical and Experimental Medicine, Division of Clinical Immunology, Linköping University, Linköping, Sweden;3. Department of Clinical Immunology and Transfusion medicine, Linköping University Hospital, Linköping, Sweden;4. Diabetes Research Centre, Linköping University Hospital, Linköping, Sweden |
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Abstract: | AimThis study aimed to explore the associations between abdominal obesity, inflammatory markers and subclinical organ damage in 740 middle-aged patients with type 2 diabetes.MethodsWaist circumference (WC) and sagittal abdominal diameter (SAD) were measured, and blood samples were analyzed for C-reactive protein (CRP) and IL-6. Carotid intima–media thickness (IMT) was evaluated by ultrasonography, and aortic pulse wave velocity (PWV) measured with applanation tonometry.ResultsAbdominal obesity as determined by SAD and WC was significantly correlated with IL-6 (WC: r = 0.27, P < 0.001; SAD: r = 031, P < 0.001), CRP (WC: r = 0.29, P < 0.001; SAD: r = 0.29, P < 0.001), IMT (WC: r = 0.09, P = 0.013; SAD: r = 0.11, P = 0.003) and PWV (WC: r = 0.18, P < 0.001; SAD: r = 0.21, P < 0.001). In multiple linear regressions with IMT and PWV as dependent variables, and age, gender, statin use, systolic blood pressure (SBP), body mass index (BMI), CRP and HbA1c as independent variables, both SAD and WC remained associated with IMT and PWV. On stepwise linear regression and entering both SAD and WC, the association between SAD and PWV was stronger than the association between WC and PWV.ConclusionBoth SAD and WC are feasible measures of obesity, and both provide information on inflammation, atherosclerosis and arterial stiffness in type 2 diabetes, while SAD appears to be slightly more robustly associated with subclinical organ damage than WC. |
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Keywords: | Type 2 diabetes Obesity Anthropometric measurements Cardiovascular disease |
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