Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage |
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| Affiliation: | 1. Bacteriology Department, Groupement Hospitalier Nord;2. Infectious Diseases Department, Hospices Civils de Lyon;3. International Centre for Research in Infectious Diseases, INSERM U1111, Université Claude Bernard Lyon 1, Lyon;4. Bacteriology Department, Montpellier University Hospitals, Montpellier;5. Bacteriology Department, Novescia, Lyon;6. Bacteriology Department, Saint Etienne University Hospitals, St Etienne;7. Bacteriology Department, HÓpital Henri-Mondor, Assistance Publique - HÓpitaux de Paris, Paris;8. Bacteriology Department, Groupement Hospitalier Est;9. French National Reference Centre for Staphylococci, Hospices Civils de Lyon, Lyon, France |
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| Abstract: | The prevalence of clonal complex (CC) 398 methicillin-susceptible Staphylococcus aureus (MSSA) was unexpectedly high among bone and joint infections (BJIs) and nasal-colonizing isolates in France, with surprising geographical heterogeneity. With none of the major, most-known staphylococcal virulence genes, MSSA CC398 BJI was associated with lower biological inflammatory syndrome and lower treatment failure rates. |
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| Keywords: | Clonal complex 398 bone and joint infection molecular epidemiology nasal carriage virulence factors |
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