稳心颗粒联合美托洛尔治疗频发性室性早搏疗效及对心率变异性影响观察

目的：观察稳心颗粒联合美托洛尔治疗频发性室性早搏（FPVC）的疗效及对患者心率变异性的影响。方法：99例患者随机分为对照组33例和观察组66例。两组均予冠心病常规治疗,对照组同时给予美托洛尔片25mg,po bid,观察组在对照组基础上加用稳心颗粒,4周为一疗程。比较两组患者的早搏次数、临床疗效、心率变异性（SDNN、rMSSD、PNN50、LF、HF、LF/HF）和药品不良反应。结果：治疗后,观察组早搏次数较治疗前明显下降（P〈0.05）,临床总有效率为92.4%,SDNN、rMSSD、PNN50、LF、HF等指标均有明显增加（P〈0.05）,上述指标与对照组比较,差异均有统计学意义（P〈0.05）。两组不良反应轻微。结论：稳心颗粒联合美托洛尔治疗FPVC疗效显著,能有效改善患者心率变异性指标。

Clinical Observations of Wenxin Granule on the Clinical Effects and Heart Rate Variability of 66 Patients with Frequent Premature Ventricniar Contractions

Objective： To observe the impacts of Wenxin granule on clinical effects and heart rate variability of patients with frequent premature ventricular contractions （FPVC）. Methods： 99 patients with FPVC were randomly divided into control group （33 cases） and observation group （66 cases）. On the basis of conventioal medical treatment for coronary heart disease, the control group received metoprolol; the observation group was treated with Wenxin granule additionally. All cases in both groups were treated for 4 weeks. The frequency of premature beats, clinical efficiency and heart rate variability （SDNN, rMSSD, PNN50, LF, HF, LF/HF） were compared, and the adverse reactions were recorded. Results：After treatment, for the observation group, the frequency of premature beats and clinical efficiency was （ 311 ± 48 ） and 92.4%, respectively; SDNN, rMSSD, PNNS0, LF and HF increased, and there were significant differences between the two groups （ P 〈 0.05 ）. No serious adverse reactions were observed for the two groups. Conclusion： Wenxin granule is suitable for the treatment of patients with frequent premature ventricular contractions.