抗心律失常药物消除L-甲状腺素诱导的心肌肥厚

目的：研究抗心律失常药物治疗Ｌ－甲状腺素诱导的心肌肥厚的效果。方法：４１只ＳＤ雄性大鼠，随机分成六组，对照组给予空白羧甲基纤维钠（１％），其他组给予Ｌ－甲状腺素１ｍｇ／ｋｇ，７天后治疗组同时分别给予氯沙坦、维拉帕米、索他洛尔、８６０１７，１０天后处死，取心脏观察心肌肥厚程度，以心脏指数为疗效指标。结果：Ｌ－甲状腺素能显著诱导心肌肥厚；四种药物均能消除心肌肥厚，其中索他洛尔和８６０１７的效果尤为显著

Antiarrhythmics reduce cardiac muscle hypertrophy induced by L thyroxin

Objectives: To investigate the effects of Antiarrhythmics in the treatment of cardiac muscle hypertrophy induced by L thyroxin. Methods: The cardiac hypertrophy model was produced by oral intake of L thyroxin 1 mg/kg for 10 days. Rats were divided into groups to administer Losartan (10 mg/kg), verapamil (10 mg/kg),sotalol (10 mg/kg) and 86017 (100 mg/kg) for 3 days. The evidence of cardiac hypertrophy was defined as an increased cardiac muscle mass (HW/BW) against normal. Results: L thyroxin obviously increased cardiac muscle mass ( P <0.05), all the four drugs could reduce cardiac muscle hypertrophy ( P <0.05). Conclusions: Antiarrhythmics can reduce cardiac muscle hypertrophy induced by L thyroxin.