活血化瘀中药防治冠状动脉介入治疗后再狭窄的Meta分析

目的:运用循证医学的方法,对活血化瘀中药防治冠状动脉介入治疗后再狭窄的临床疗效进行Meta分析。方法:全面收集活血化瘀中药防治冠状动脉介入治疗后再狭窄的临床试验资料,采用Jadad质量标准对文献进行评价,并利用RevMan4.2软件对多个研究结果的总体效应进行Meta分析,并进行敏感性分析;用漏斗图分析发表性偏倚。结果:13篇文献符合纳入标准,只有2篇双盲试验被评为高质量文献。活血化瘀中药防治冠状动脉介入治疗后心绞痛复发率和再狭窄率的疗效分析中,试验组复发率均低于对照组,且差异有统计学意义。敏感性分析,显示评价结果较为稳定;漏斗图图形不对称,考虑存在发表性偏倚。结论:活血化瘀法防治冠状动脉介入治疗后再狭窄有一定的疗效,在改善患者心绞痛复发率方面也有一定的优势。

Meta-Analysis of Chinese Herb of Promoting Blood Circulation to Dissipate Blood Stasis in Preventing and Treating Restenosis after Percutaneous Coronary Intervention

In accordance with the principle of evidence-based medicine,the efficacy of Chinese herb of promoting blood circulation to dissipate blood stasis in preventing and treating restenosis after PCI are analyzed and Method is Meta-Analysis.Methods:All reports of clinical trials of Chinese herb of promoting blood circulation to dissipate blood stasis in preventing and treating restenosis after PCI were collected.All literatures were assessed via Jadad quality standard and the Meta-Analysis to the total effect of the study results was evaluated by the statistical software of RevMan4.2.Sensitivity were analyzed;funnel-plot analysis was used to identify the publication bias.Results:Thirteen reports were identified.Only two double blind trials were appraised as high quality in methodology.According to therapeutic analysis of Chinese herb of promoting blood circulation to dissipate blood stasis in preventing and treating restenosis after PCI.The relapse rate of the treatment group is lower than of the control group,and differences have statistics significance.Sensitivity analysis reveals a relatively stabe result;Funnel plot is asymmetrical,which shows the possible existence of publication bias.Conclusion:Chinese herb of promoting blood circulation to dissipate blood stasis in preventing and treating restenosis after PCI have certain therapeutic effect,and there is certain superiority on improving patients'angina pectoris recurrence rate.